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Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
scientific article published on 01 July 2000
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
title
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
main subject
insulin resistance
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author
Catherine Postic
series ordinal
3
1 reference
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Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
Gerald I. Shulman
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5
1 reference
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Europe PubMed Central
PubMed ID
10949030
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
Stephen F Previs
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4
object named as
S F Previs
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Europe PubMed Central
PubMed ID
10949030
reference URL
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9 November 2019
author name string
M D Michael
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1
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Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
R N Kulkarni
series ordinal
2
1 reference
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Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
M A Magnuson
series ordinal
6
1 reference
stated in
Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
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9 November 2019
C R Kahn
series ordinal
7
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Europe PubMed Central
PubMed ID
10949030
reference URL
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9 November 2019
publication date
1 July 2000
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Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
published in
Molecular Cell
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Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
volume
6
1 reference
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Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
page(s)
87-97
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Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
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7 January 2021
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Insulin Removal in Man:In VivoEvidence for a Receptor-Mediated Process*
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Stabilization of tubulin mRNAs by insulin and insulin-like growth factor I during neurite formation
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Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
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ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
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Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
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Cultured hepatoma cells as a model system for studying insulin processing and biologic responsiveness
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Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.
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Cell-specific Expression and Regulation of a Glucokinase Gene Locus Transgene
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Effects of Increased Glucokinase Gene Copy Number on Glucose Homeostasis and Hepatic Glucose Metabolism
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7 January 2021
based on heuristic
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Regulation of gene expression by insulin
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Long-term effects of insulin on the enzyme activity and messenger RNA of glycogen synthase in rat hepatoma H4 cells: an effect of insulin on glycogen synthase mRNA stability
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
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7 January 2021
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inferred from DOI database lookup
DNA excision in liver by an albumin-Cre transgene occurs progressively with age
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular mechanisms for the control of translation by insulin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucose regulation of hepatic gluconeogenesis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mode of uptake and degradation of 125I-labelled insulin by isolated hepatocytes and H4 hepatoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoglycemia associated with lipid accumulation in primary hepatocellular carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of in vivo and in vitro techniques for the study of the effects of insulin on hepatic triacylglycerol secretion in different insulinaemic states
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Renal metabolism of C-peptide in man
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900015-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1097-2765(05)00015-8
1 reference
stated in
Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
PubMed ID
10949030
1 reference
stated in
Europe PubMed Central
PubMed ID
10949030
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10949030%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
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