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English
Agonist-independent regulation of constitutively active G-protein-coupled receptors
scientific article published on 01 November 1998
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
Agonist-independent regulation of constitutively active G-protein-coupled receptors
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
author name string
R Leurs
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
M J Smit
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
A E Alewijnse
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
H Timmerman
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
publication date
1 November 1998
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
number of pages
5
1 reference
based on heuristic
inferred from page(s)
published in
Trends in Biochemical Sciences
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
volume
23
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
page(s)
418-422
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
issue
11
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
cites work
How receptors talk to trimeric G proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901287-0
retrieved
7 January 2021
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Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin
1 reference
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reference URL
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Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins
1 reference
stated in
Crossref
reference URL
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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
1 reference
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Inverse agonism: pharmacological curiosity or potential therapeutic strategy?
1 reference
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Crossref
reference URL
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7 January 2021
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Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor
1 reference
stated in
Crossref
reference URL
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A three-state receptor model of agonist action
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
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Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation
1 reference
stated in
Crossref
reference URL
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7 January 2021
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The elusive nature of intrinsic efficacy.
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for multiple, biochemically distinguishable states in the G protein-coupled receptor, rhodopsin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901287-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
G protein-coupled receptors. II. Mechanism of agonist activation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901287-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutively active mutants of rhodopsin
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Activation of the alpha1b-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901287-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2898%2901287-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment
1 reference
stated in
Crossref
reference URL
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Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.
1 reference
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Crossref
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7 January 2021
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Up-regulation of a constitutively active form of the beta2-adrenoceptor by sustained treatment with inverse agonists but not antagonists
1 reference
stated in
Crossref
reference URL
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Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors
1 reference
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Defects in G protein-coupled signal transduction in human disease
1 reference
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Crossref
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G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity
1 reference
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Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation
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Crossref
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G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator
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Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors
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G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration
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1 reference
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7 January 2021
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Identifiers
DOI
10.1016/S0968-0004(98)01287-0
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
PubMed ID
9852759
1 reference
stated in
Europe PubMed Central
PubMed ID
9852759
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9852759%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 December 2019
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