(Q80102518)

English

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

scientific article published on 13 August 2006

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scholarly article

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28 December 2019

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system (English)

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28 December 2019

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28 December 2019

Alejandro Villarino

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28 December 2019

Lothar Hennighausen

13

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28 December 2019

author name string

Jason S Stumhofer

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28 December 2019

Emma H Wilson

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28 December 2019

Elaine Huang

4

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28 December 2019

Cristina M Tato

5

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28 December 2019

Leanne M Johnson

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28 December 2019

Qiulong Huang

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28 December 2019

Akihiko Yoshimura

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28 December 2019

David Sehy

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28 December 2019

Christiaan J M Saris

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28 December 2019

John J O'Shea

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28 December 2019

Christopher A Hunter

15

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28 December 2019

publication date

13 August 2006

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28 December 2019

Nature Immunology

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28 December 2019

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28 December 2019

937-945

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28 December 2019

9

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28 December 2019

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Understanding the IL-23-IL-17 immune pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming growth factor-beta induces development of the T(H)17 lineage

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and characterization of a novel class I cytokine receptor

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Gp130 and the interleukin-6 family of cytokines

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-27 limits IL-2 production during Th1 differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

CTLA-4: new insights into its biological function and use in tumor immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

SOCS3 negatively regulates IL-6 signaling in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma.

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Blockade of costimulation prevents infection-induced immunopathology in interleukin-10-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNI1376

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

1 reference

Europe PubMed Central

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28 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16906166%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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