(Q80969122)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

main subject

phase I clinical trial

1 reference

12

Mark J Ratain

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

author name string

John L Marshall

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Hedy Kindler

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

John Deeken

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Pankaj Bhargava

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Nicholas J Vogelzang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Naiyer Rizvi

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Taina Luhtala

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Stacy Boylan

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Margaret Dordal

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Philmore Robertson

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Michael J Hawkins

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

publication date

1 January 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

Investigational New Drugs

4 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

page(s)

31-37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15528978%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1023/b:drug.0000047103.64335.b0

4 January 2020

exact match

0 references

cites work

Immunohistochemical analysis of TrkA neurotrophin receptor expression in human non-neuronal carcinomas

1 reference

12 December 2020

Molecular characterization of neurotrophin expression and the corresponding tropomyosin receptor kinases (trks) in epithelial and stromal cells of the human prostate

1 reference

12 December 2020

Expression of a Trk high affinity nerve growth factor receptor in the human prostate

1 reference

12 December 2020

Identification of the neurotrophin receptors p75 and trk in a series of Wilms' tumors

1 reference

12 December 2020

CEP-751 inhibits TRK receptor tyrosine kinase activity in vitro exhibits anti-tumor activity

1 reference

12 December 2020

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1 reference

12 December 2020

Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior

1 reference

12 December 2020

Nerve growth factor stimulates clonal growth of human lung cancer cell lines and a human glioblastoma cell line expressing high-affinity nerve growth factor binding sites involving tyrosine kinase signaling

1 reference

12 December 2020

Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

1 reference

12 December 2020

Intracellular signaling pathways activated by neurotrophic factors

1 reference

12 December 2020

High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma

1 reference

12 December 2020

Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells.

1 reference

12 December 2020

K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity

1 reference

12 December 2020

Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587)

1 reference

12 December 2020

Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase

1 reference

12 December 2020

Role of nerve growth factor-like protein in the paracrine regulation of prostate growth

1 reference

12 December 2020

Mutational analysis of the TrkA gene in prostate cancer.

1 reference

12 December 2020

Antitumor activity of CEP-751 (KT-6587) on human neuroblastoma and medulloblastoma xenografts

1 reference

12 December 2020

Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells

1 reference

12 December 2020

Prodrug esters of the indolocarbazole CEP-751 (KT-6587)

1 reference

12 December 2020

Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)

1 reference

12 December 2020

Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations.

1 reference

12 December 2020

The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Antitumor effect of KT6124, a novel derivative of protein kinase inhibitor K-252a, and its mechanism of action

1 reference

12 December 2020

Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein.

1 reference

12 December 2020

Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues

1 reference

12 December 2020