Wikidata

(Q9020944)

English

LCK proto-oncogene, Src family tyrosine kinase

mammalian protein found in Homo sapiens

  • T-lymphocyte specific protein tyrosine kinase p56lck
  • proto-oncogene tyrosine-protein kinase LCK
  • LSK
  • p56-LCK
  • lymphocyte cell-specific protein-tyrosine kinase
  • leukocyte C-terminal Src kinase
  • Protein YT16
  • p56(LSTRA) protein-tyrosine kinase
  • tyrosine-protein kinase Lck
  • Proto-oncogene Lck
  • LCK
  • t cell-specific protein-tyrosine kinase
  • Tyrosine-protein kinase Lck
In more languages

Statements

molecular function
protein binding
determination method
IPI
51 references
retrieved
8 April 2019
stated in
BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of SRC tyrosine kinases suppresses activation of nuclear factor-kappa B, and serine and tyrosine phosphorylation of Ikappa B-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
PKD2 interacts with Lck and regulates NFAT activity in T cells
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis for regulation of Src by the docking protein p130Cas
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of Lck-binding elements in the herpesviral regulatory Tip protein
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Identification of substrates of human protein-tyrosine phosphatase PTPN22
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Large-scale structural analysis of the classical human protein tyrosine phosphatome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of Bcl-3 through interaction with the Lck tyrosine kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Distinct interactions between ubiquitin and the SH3 domains involved in immune signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
p70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of the Tio oncoprotein is essential for transformation of primary human T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
retrieved
8 April 2019
stated in
The C terminus of T cell-specific adapter protein (TSAd) is necessary for TSAd-mediated inhibition of Lck activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IPI
protein tyrosine kinase activity
determination method
EXP
IDA
IEA
IMP
ISS
TAS
10 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
ISS
retrieved
1 January 2018
stated in
Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
IEA
retrieved
1 January 2018
stated in
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
IDA
retrieved
1 January 2018
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
EXP
retrieved
1 January 2018
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
EXP
retrieved
1 January 2018
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
EXP
retrieved
1 January 2018
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P06239&geneProductId=UniProtKB:P06239
determination method
EXP
protein tyrosine kinase activity
determination method
EXP
IDA
IEA
IMP
TAS
9 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
TAS
retrieved
8 April 2019
stated in
Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IEA
retrieved
8 April 2019
stated in
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein
GOA
curator
UniProt
UniProt protein ID
P06239
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
IDA
retrieved
8 April 2019
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
EXP
retrieved
8 April 2019
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
EXP
retrieved
8 April 2019
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
EXP
retrieved
8 April 2019
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06239
determination method
EXP
cell component
biological process
Gene Atlas image
PBB GE LCK 204891 s at fs.png
732 × 530; 10 KB
0 references

Identifiers

MeSH descriptor ID
D019860
subject named as
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
0 references
PDB structure ID
 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q9020944&oldid=2117633440"