(Q14904318)

Dwarfin

1 reference

SMAD MH1 domain superfamily

1 reference

SMAD/FHA domain superfamily

1 reference

MAD homology, MH1, protein family

1 reference

based on heuristic

inferred from protein domain or family

SMAD domain, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

MAD homology 1, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

type I transforming growth factor beta receptor binding

1 reference

8 April 2019

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

1 reference

8 April 2019

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

1 reference

8 April 2019

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

DNA-binding transcription factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

1 reference

8 April 2019

Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

type I activin receptor binding

1 reference

8 April 2019

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

3 references

8 April 2019

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

8 April 2019

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

8 April 2019

Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

identical protein binding

1 reference

8 April 2019

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

ubiquitin protein ligase binding

1 reference

8 April 2019

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

1 reference

8 April 2019

Holding their own: the noncanonical roles of Smad proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

transcription regulator complex

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

intracellular anatomical structure

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43541&geneProductId=UniProtKB:O43541

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

8 April 2019

Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

protein-containing complex

1 reference

8 April 2019

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

biological process

ureteric bud development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

heart valve development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

ventricular septum development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

zygotic specification of dorsal/ventral axis

1 reference

8 April 2019

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

negative regulation of SMAD protein complex assembly

1 reference

8 April 2019

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

response to laminar fluid shear stress

1 reference

8 April 2019

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

negative regulation of apoptotic process

IEP

1 reference

8 April 2019

SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

negative regulation of transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

coronary vasculature development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43541&geneProductId=UniProtKB:O43541

negative regulation of pathway-restricted SMAD protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

negative regulation of BMP signaling pathway

1 reference

27 March 2018

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43541&geneProductId=UniProtKB:O43541

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation

cell-substrate adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

1 reference

8 April 2019

Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6

fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

negative regulation of cell population proliferation

1 reference

8 April 2019

SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

aortic valve morphogenesis

1 reference

8 April 2019

Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

negative regulation of osteoblast differentiation

1 reference

8 April 2019

Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

response to lipopolysaccharide

1 reference

8 April 2019

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43541

MAD homology 1, Dwarfin-type

Gene Atlas image

PBB GE SMAD6 207069 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

1 reference

SMAD domain, Dwarfin-type

1 reference

MAD homology, MH1

1 reference