(Q43758292)

26 November 2017

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells (English)

1 reference

26 November 2017

1 reference

He-Jin Lee

1

1 reference

PubMed ID

12351642

26 November 2017

Seung-Jae Lee

series ordinal

2

1 reference

PubMed ID

12351642

26 November 2017

language of work or name

English

0 references

publication date

25 September 2002

1 reference

Journal of Biological Chemistry

26 November 2017

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26 November 2017

277

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26 November 2017

50

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26 November 2017

48976-48983

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Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

26 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Alpha-synuclein and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Neurodegenerative disease: amyloid pores from pathogenic mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

A detergent-insoluble membrane compartment contains A beta in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Dynamic nature of host-pathogen interactions in Mycobacterium marinum granulomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Aggresomes: a cellular response to misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Nucleated conformational conversion and the replication of conformational information by a prion determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Hassles with taking out the garbage: aggravating aggresomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Specificity in intracellular protein aggregation and inclusion body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208192200

21 January 2018

Identifiers

DOI

10.1074/JBC.M208192200

1 reference

26 November 2017

1 reference

PubMed ID

12351642