(Q88876114)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29804838%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

title

Structural Basis of Smoothened Activation in Hedgehog Signaling (English)

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28 March 2020

3

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28 March 2020

author name string

Pengxiang Huang

1

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28 March 2020

Sanduo Zheng

2

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28 March 2020

Youngchang Kim

4

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28 March 2020

Daniel Nedelcu

5

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28 March 2020

Laura Aravena

6

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28 March 2020

Jing Liu

7

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28 March 2020

Andrew C Kruse

8

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28 March 2020

Adrian Salic

9

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28 March 2020

publication date

24 May 2018

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28 March 2020

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28 March 2020

volume

174

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28 March 2020

issue

2

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28 March 2020

page(s)

312-324.e16

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A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

28 March 2020

cites work

1 reference

12 December 2020

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1 reference

12 December 2020

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

1 reference

12 December 2020

Activating Smoothened mutations in sporadic basal-cell carcinoma

1 reference

12 December 2020

Cation-pi interactions in structural biology

1 reference

12 December 2020

1998 Warkany lecture: signaling pathways in development

1 reference

12 December 2020

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

1 reference

12 December 2020

Hedgehog signaling in animal development: paradigms and principles

1 reference

12 December 2020

Patched acts catalytically to suppress the activity of Smoothened

1 reference

12 December 2020

Small molecule modulation of Smoothened activity

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12 December 2020

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

1 reference

12 December 2020

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

1 reference

12 December 2020

The Hedgehog response network: sensors, switches, and routers

1 reference

12 December 2020

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

1 reference

12 December 2020

Coot: model-building tools for molecular graphics

1 reference

12 December 2020

Vertebrate Smoothened functions at the primary cilium

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12 December 2020

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

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12 December 2020

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

1 reference

12 December 2020

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

1 reference

12 December 2020

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

12 December 2020

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

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12 December 2020

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

1 reference

12 December 2020

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium

1 reference

12 December 2020

Crystallizing membrane proteins using lipidic mesophases

1 reference

12 December 2020

Phasercrystallographic software

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12 December 2020

GDC-0449-a potent inhibitor of the hedgehog pathway

1 reference

12 December 2020

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics

1 reference

12 December 2020

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

1 reference

12 December 2020

Crystal structure of metarhodopsin II

1 reference

12 December 2020

Crystal structure of the β2 adrenergic receptor-Gs protein complex

1 reference

12 December 2020

Oxysterols are allosteric activators of the oncoprotein Smoothened

1 reference

12 December 2020

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

1 reference

12 December 2020

Structural basis of Wnt recognition by Frizzled

1 reference

12 December 2020

Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand

1 reference

12 December 2020

Structure of the human smoothened receptor bound to an antitumour agent

1 reference

12 December 2020

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

1 reference

12 December 2020

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

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12 December 2020

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

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12 December 2020

Activation and allosteric modulation of a muscarinic acetylcholine receptor

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12 December 2020

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

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12 December 2020

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs

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12 December 2020

Extra-helical binding site of a glucagon receptor antagonist

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12 December 2020

Structural basis of Smoothened regulation by its extracellular domains

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12 December 2020

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

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12 December 2020

Polder maps: improving OMIT maps by excluding bulk solvent.

1 reference

12 December 2020

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

1 reference

12 December 2020

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

1 reference

12 December 2020

Structural Basis for G Protein-Coupled Receptor Activation

1 reference

12 December 2020

Extending the Structural View of Class B GPCRs.

1 reference

12 December 2020

10.1016/J.CELL.2018.04.029

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29804838%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

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28 March 2020

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