(Q100152398)

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PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9665407)

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8 July 2022

Signaling by ERBB2 ECD mutants

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13 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-9665407

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8 July 2022

1

object of statement has role

1 reference

8 July 2022

1

object of statement has role

1 reference

8 July 2022

p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)

quantity

1

object of statement has role

1 reference

8 July 2022

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)

quantity

1

object of statement has role

1 reference

8 July 2022

Activating HER2 mutations in HER2 gene amplification negative breast cancer

1 reference

8 July 2022

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q100152398)

PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3

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