(Q100153886)

English

F8 variant does not bind von Willebrand factor

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9665809)

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1 reference

8 July 2022

Defective F8 binding to von Willebrand factor

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9665809

1 reference

8 July 2022

F8 C1,C2 domains variants [extracellular region]

quantity

1

object of statement has role

1 reference

8 July 2022

von Willibrand factor multimer [extracellular region]

quantity

1

object of statement has role

1 reference

8 July 2022

Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development.

1 reference

8 July 2022

Storage of factor VIII variants with impaired von Willebrand factor binding in Weibel-Palade bodies in endothelial cells

1 reference

8 July 2022

A novel cause of mild/moderate hemophilia A: mutations scattered in the factor VIII C1 domain reduce factor VIII binding to von Willebrand factor

1 reference

8 July 2022

Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q100153886)

F8 variant does not bind von Willebrand factor

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