(Q100153889)

English

FVIIIa variant:FIXa does not convert FX to the active FXa

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9668365)

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Statements

biological process

1 reference

8 July 2022

Defective cofactor function of FVIIIa variant

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9668365

1 reference

8 July 2022

20

object has role

1 reference

8 July 2022

factor X [extracellular region]

1

object has role

1 reference

8 July 2022

FVIIIa variant:FIXa [plasma membrane]

1

object has role

1 reference

8 July 2022

Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex

1 reference

8 July 2022

Substitution of Arg527 and Arg531 in factor VIII associated with mild haemophilia A: characterization in terms of subunit interaction and cofactor function

1 reference

8 July 2022

The molecular basis for cross-reacting material-positive hemophilia A due to missense mutations within the A2-domain of factor VIII.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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