(Q100153895)

English

FIXa variant:FVIIIa does not convert FX to the active FXa

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9670874)

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Statements

1 reference

8 July 2022

Defective F9 variant does not activate FX

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9670874

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8 July 2022

20

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8 July 2022

factor X [extracellular region]

1

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8 July 2022

factor VIIIa:factor IXa variant [plasma membrane]

1

1 reference

8 July 2022

Expression and Characterization of Gly-317 Variants of Factor IX Causing Variable Bleeding in Hemophilia B Patients

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8 July 2022

Characterization of three abnormal factor IX variants (Bm Lake Elsinore, Long Beach, and Los Angeles) of hemophilia-B. Evidence for defects affecting the latent catalytic site

1 reference

8 July 2022

Factor IX Amagasaki: a new mutation in the catalytic domain resulting in the loss of both coagulant and esterase activities

1 reference

8 July 2022

Experimental and theoretical evidence supporting the role of Gly363 in blood coagulation factor IXa (Gly193 in chymotrypsin) for proper activation of the proenzyme

1 reference

8 July 2022

Hemophilia B caused by five different nondeletion mutations in the protease domain of factor IX

1 reference

8 July 2022

Replacement of isoleucine-397 by threonine in the clotting proteinase factor IXa (Los Angeles and Long Beach variants) affects macromolecular catalysis but not L-tosylarginine methyl ester hydrolysis. Lack of correlation between the ox brain prothro

1 reference

8 July 2022

Factor IX Bm Kiryu: a Val-313-to-Asp substitution in the catalytic domain results in loss of function due to a conformational change of the surface loop: evidence obtained by chimaeric modelling

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q100153895)

FIXa variant:FVIIIa does not convert FX to the active FXa

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