(Q100162418)

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Estrogen receptor binds IGF1R and SHC1 in response to estrogen

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9634584)

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8 July 2022

Extra-nuclear estrogen signaling

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-9634584

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8 July 2022

ESTG:Me260-ESR1 dimer [cytosol]

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8 July 2022

p-Y1161,1165,1166-IGF1R [plasma membrane]

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8 July 2022

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8 July 2022

ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane]

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8 July 2022

Estradiol stimulates tyrosine phosphorylation of the insulin-like growth factor-1 receptor and insulin receptor substrate-1 in the uterus

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8 July 2022

Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse.

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8 July 2022

Modulation of insulin-like growth factor I (IGF-I) receptors and membrane-associated IGF-binding proteins in endometrial cancer cells by estradiol

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8 July 2022

Enhancement of Insulin-Like Growth Factor Signaling in Human Breast Cancer: Estrogen Regulation of Insulin Receptor Substrate-1 Expressionin Vitroandin Vivo

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8 July 2022

Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway

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8 July 2022

Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation

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8 July 2022

The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane

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8 July 2022

Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src

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8 July 2022

Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells

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8 July 2022

Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q100162418)

Estrogen receptor binds IGF1R and SHC1 in response to estrogen

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