(Q100235154)

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FCGR3A-mediated IL10 synthesis

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9664323)

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1 reference

8 July 2022

negative regulation of inflammatory response to antigenic stimulus

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8 July 2022

Anti-inflammatory response favouring Leishmania parasite infection

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-9664323

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8 July 2022

IgG binds LPG1G2 in the amastigote form of Leishmania

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8 July 2022

IgG binds the surface of the amastigote form of Leishmania

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8 July 2022

Opsonized leishmania amastigote binds FCGR3

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8 July 2022

Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers

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8 July 2022

SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers

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8 July 2022

Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

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8 July 2022

Recruitment of PLCgamma to membrane due to FCGR3A effect

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Phosphorylation and activation of PLCG due to FCGR3A effect

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Release of PLCG from FCGR3A

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PLC-gamma1 hydrolyses PIP2

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IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

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IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol

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Calcium binds calmodulin

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Adenylate cyclase produces cAMP

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cAMP binds PKA tetramer

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cAMP induces dissociation of inactive PKA tetramers

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PKA catalytic subunit translocates to the nucleus

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PKA phosphorylates CREB1

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CREB1 binds IL-10 promoter

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IL10 gene produces IL10 protein

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8 July 2022

Interleukin-10 therapy--review of a new approach

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8 July 2022

Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages

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8 July 2022

IgG1 is pathogenic in Leishmania mexicana infection

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8 July 2022

IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q100235154)

FCGR3A-mediated IL10 synthesis

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