(Q112978282)

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BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9709571)

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8 July 2022

Impaired BRCA2 binding to RAD51

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9709571

1 reference

8 July 2022

ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]

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1

object of statement has role

1 reference

8 July 2022

BRCA2 mutants (RAD51 binding):SEM1 [nucleoplasm]

quantity

1

object of statement has role

1 reference

8 July 2022

p-T309-RAD51 [nucleoplasm]

quantity

1

object of statement has role

1 reference

8 July 2022

Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control

1 reference

8 July 2022

Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

1 reference

8 July 2022

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q112978282)

BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51

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