(Q14864795)

English

Adenosine deaminase

mammalian protein found in Mus musculus

adenosine aminohydrolase
Ada
adenosine deaminase

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

adenosine deaminase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P03958

Metal-dependent hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P03958

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Adenosine/AMP deaminase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Adenosine/AMP deaminase active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

deaminase activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

zinc ion binding

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

adenosine deaminase activity

determination method

19 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Brain purines in a genetic mouse model of Lesch-Nyhan disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Structural and functional analysis of the murine adenosine deaminase gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

adenosine deaminase activity

determination method

20 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Brain purines in a genetic mouse model of Lesch-Nyhan disease

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Structural and functional analysis of the murine adenosine deaminase gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

cytoplasmic vesicle

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

cytoplasmic vesicle lumen

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

determination method

3 references

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

determination method

3 references

external side of plasma membrane

determination method

3 references

determination method

3 references

plasma membrane

determination method

3 references

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Transcription factor gene AP-2 gamma essential for early murine development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

biological process

negative regulation of penile erection

determination method

1 reference

14 February 2019

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of T cell differentiation

determination method

trophectodermal cell differentiation

determination method

1 reference

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of alpha-beta T cell differentiation

determination method

3 references

14 February 2019

Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

regulation of circadian sleep/wake cycle, sleep

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of calcium-mediated signaling

determination method

1 reference

14 February 2019

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

Peyer's patch development

determination method

1 reference

14 February 2019

Function of murine adenosine deaminase in the gastrointestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of germinal center formation

determination method

1 reference

14 February 2019

Impaired germinal center maturation in adenosine deaminase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

lung development

determination method

1 reference

14 February 2019

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of smooth muscle contraction

determination method

1 reference

14 February 2019

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of heart rate

determination method

1 reference

14 February 2019

Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

xanthine biosynthetic process

determination method

1 reference

14 February 2019

Function of murine adenosine deaminase in the gastrointestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

placenta development

determination method

1 reference

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

germinal center B cell differentiation

determination method

1 reference

14 February 2019

Impaired germinal center maturation in adenosine deaminase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of T cell receptor signaling pathway

determination method

1 reference

14 February 2019

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

negative regulation of thymocyte apoptotic process

determination method

negative regulation of mature B cell apoptotic process

determination method

1 reference

14 February 2019

Impaired germinal center maturation in adenosine deaminase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of T cell differentiation in thymus

determination method

4 references

14 February 2019

Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

hypoxanthine biosynthetic process

determination method

1 reference

14 February 2019

Function of murine adenosine deaminase in the gastrointestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

lung alveolus development

determination method

1 reference

14 February 2019

Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of T cell activation

determination method

regulation of T cell differentiation

determination method

1 reference

14 February 2019

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

response to hydrogen peroxide

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

embryonic digestive tract development

determination method

1 reference

14 February 2019

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

nucleotide metabolic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

positive regulation of B cell proliferation

determination method

1 reference

14 February 2019

Impaired germinal center maturation in adenosine deaminase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

purine ribonucleoside monophosphate biosynthetic process

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

negative regulation of inflammatory response

determination method

8 references

14 February 2019

Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

negative regulation of mucus secretion

determination method

4 references

14 February 2019

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

negative regulation of leukocyte migration

determination method

4 references

14 February 2019

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

deoxyadenosine catabolic process

determination method

7 references

14 February 2019

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Impaired germinal center maturation in adenosine deaminase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Function of murine adenosine deaminase in the gastrointestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

dATP catabolic process

determination method

5 references

14 February 2019

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Impaired germinal center maturation in adenosine deaminase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

inosine biosynthetic process

determination method

13 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Function of murine adenosine deaminase in the gastrointestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

adenosine catabolic process

determination method

22 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Impaired germinal center maturation in adenosine deaminase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Function of murine adenosine deaminase in the gastrointestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Structural and functional analysis of the murine adenosine deaminase gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

24 April 2018

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03958&geneProductId=UniProtKB:P03958

determination method

hypoxanthine salvage

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

negative regulation of adenosine receptor signaling pathway

determination method

3 references

adenosine catabolic process

determination method

23 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Impaired germinal center maturation in adenosine deaminase deficiency

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Function of murine adenosine deaminase in the gastrointestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Structural and functional analysis of the murine adenosine deaminase gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

T cell activation

determination method

3 references

inosine biosynthetic process

determination method

14 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Function of murine adenosine deaminase in the gastrointestinal tract

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03958

determination method

Adenosine/AMP deaminase active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P03958

Adenosine/AMP deaminase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P03958

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000017841

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000017841

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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