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(Q14865204)
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English
Beta-site APP-cleaving enzyme 2
mammalian protein found in Mus musculus
ASP1
membrane-associated aspartic protease 1
aspartyl protease 1
beta-secretase 2
Beta-site APP cleaving enzyme 2
theta-secretase
Asp 1
memapsin-1
beta-site amyloid precursor protein cleaving enzyme 2
Bace2
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
31 January 2018
UniProt protein ID
Q9JL18
part of
Aspartic peptidase domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9JL18
Beta-secretase BACE2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9JL18
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
Memapsin-like, protein family
1 reference
based on heuristic
inferred from protein domain or family
Peptidase family A1 domain
1 reference
based on heuristic
inferred from protein domain or family
Aspartic peptidase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
house mouse
1 reference
stated in
UniProt
retrieved
31 January 2018
UniProt protein ID
Q9JL18
encoded by
Bace2
1 reference
stated in
UniProt
retrieved
31 January 2018
UniProt protein ID
Q9JL18
molecular function
peptidase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
amyloid-beta binding
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
hydrolase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
aspartic-type endopeptidase activity
determination method
IBA
ISS
IEA
ISO
5 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
cell component
integral component of membrane
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
cell surface
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
endosome
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JL18&geneProductId=UniProtKB:Q9JL18
determination method
IEA
Golgi apparatus
determination method
IBA
ISS
IEA
ISO
4 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
endoplasmic reticulum
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JL18&geneProductId=UniProtKB:Q9JL18
determination method
IEA
plasma membrane
determination method
IDA
ISO
2 references
retrieved
7 November 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JL18&geneProductId=UniProtKB:Q9JL18
determination method
ISO
retrieved
7 November 2018
stated in
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JL18&geneProductId=UniProtKB:Q9JL18
determination method
IDA
endosome
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
trans-Golgi network
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
membrane
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
cytoplasm
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISO
dense core granule
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISO
plasma membrane
determination method
IDA
IEA
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IDA
biological process
protein catabolic process
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
amyloid-beta metabolic process
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
membrane protein ectodomain proteolysis
determination method
IBA
ISS
ISO
3 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISO
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
proteolysis
determination method
IEA
2 references
retrieved
27 March 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JL18&geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9JL18&geneProductId=UniProtKB:Q9JL18
determination method
IEA
negative regulation of amyloid precursor protein biosynthetic process
determination method
ISS
ISO
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISO
proteolysis
determination method
IBA
IEA
3 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9JL18
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
IBA
glucose homeostasis
determination method
ISO
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JL18
determination method
ISO
has part(s)
Peptidase family A1 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9JL18
Aspartic peptidase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9JL18
Memapsin-like
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9JL18
Identifiers
RefSeq protein ID
NP_062390
1 reference
stated in
NCBI Gene
retrieved
24 February 2018
Entrez Gene ID
56175
XP_006523131
1 reference
stated in
NCBI Gene
retrieved
24 February 2018
Entrez Gene ID
56175
UniProt protein ID
Q9JL18
1 reference
stated in
UniProt
retrieved
31 January 2018
UniProt protein ID
Q9JL18
Ensembl protein ID
ENSMUSP00000043918
1 reference
stated in
ensembl Release 92
Ensembl protein ID
ENSMUSP00000043918
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