(Q14873917)

English

Phospholamban

mammalian protein found in Mus musculus

cardiac phospholamban
Pln
uniprot:P61014

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61014

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

calcium channel regulator activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

protein binding

determination method

3 references

9 May 2019

Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

9 May 2019

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

9 May 2019

Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

protein homodimerization activity

determination method

1 reference

9 May 2019

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

integral component of membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

endoplasmic reticulum membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

mitochondrial membranes

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

calcium ion-transporting ATPase complex

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

sarcoplasmic reticulum

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

9 May 2019

Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

biological process

Notch signaling pathway

determination method

1 reference

9 May 2019

Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

regulation of ryanodine-sensitive calcium-release channel activity

determination method

1 reference

9 May 2019

Phospholamban ablation and compensatory responses in the mammalian heart

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

negative regulation of calcium ion binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

cardiac muscle tissue development

determination method

1 reference

9 May 2019

Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

negative regulation of heart contraction

determination method

regulation of the force of heart contraction

determination method

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

determination method

1 reference

9 May 2019

Simultaneous measurement of intracellular calcium and ventricular function in the phospholamban-deficient mouse heart

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

negative regulation of ATP-dependent activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

regulation of ATPase-coupled calcium transmembrane transporter activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

regulation of calcium ion import

determination method

1 reference

9 May 2019

Phospholamban gene dosage effects in the mammalian heart

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

cellular calcium ion homeostasis

determination method

1 reference

9 May 2019

Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

negative regulation of calcium ion transmembrane transporter activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

negative regulation of heart rate

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

response to insulin

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

regulation of cardiac muscle cell contraction

determination method

1 reference

9 May 2019

Phospholamban gene dosage effects in the mammalian heart

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

negative regulation of ATPase-coupled calcium transmembrane transporter activity

determination method

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

negative regulation of calcium ion transport

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

determination method

1 reference

9 May 2019

The effect of isoproterenol on phospholamban-deficient mouse hearts with altered thyroid conditions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

regulation of the force of heart contraction by cardiac conduction

determination method

1 reference

9 May 2019

Phospholamban: a major determinant of the cardiac force-frequency relationship

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

regulation of relaxation of muscle

determination method

1 reference

9 May 2019

Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

determination method

1 reference

9 May 2019

Targeted ablation of the phospholamban gene is associated with a marked decrease in sensitivity in aortic smooth muscle

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

negative regulation of calcium ion import into sarcoplasmic reticulum

determination method

1 reference

9 May 2019

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61014

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000045709

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000045709

ENSMUSP00000132743

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000132743

ENSMUSP00000151641

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000151641

ENSMUSP00000151745

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000151745

ENSMUSP00000151860

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000151860

ENSMUSP00000151966

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000151966

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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