(Q14874308)

English

Klotho

mammalian protein found in Mus musculus

klotho
Kl
uniprot:O35082
secreted form of Klotho protein

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35082

glycoside hydrolase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35082

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Glycosyl hydrolases family 1, N-terminal conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

hydrolase activity, hydrolyzing O-glycosyl compounds

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

fibroblast growth factor receptor binding

determination method

1 reference

24 April 2018

Klotho converts canonical FGF receptor into a specific receptor for FGF23

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35082&geneProductId=UniProtKB:O35082

determination method

beta-glucuronidase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

hydrolase activity, acting on glycosyl bonds

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

protein binding

determination method

4 references

14 February 2019

Regulation of fibroblast growth factor-23 signaling by klotho

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

Klotho converts canonical FGF receptor into a specific receptor for FGF23

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

Augmented Wnt signaling in a mammalian model of accelerated aging

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

fibroblast growth factor binding

determination method

3 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35082&geneProductId=UniProtKB:O35082

determination method

24 April 2018

Klotho converts canonical FGF receptor into a specific receptor for FGF23

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35082&geneProductId=UniProtKB:O35082

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35082&geneProductId=UniProtKB:O35082

determination method

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

beta-glucosidase activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

fibroblast growth factor binding

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

Klotho converts canonical FGF receptor into a specific receptor for FGF23

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

integral component of membrane

determination method

3 references

14 February 2019

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

apical plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

integral component of plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35082&geneProductId=UniProtKB:O35082

determination method

extracellular space

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

biological process

insulin receptor signaling pathway

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

calcium ion homeostasis

determination method

1 reference

14 February 2019

Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

fibroblast growth factor receptor signaling pathway

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

determination method

1 reference

14 February 2019

Regulation of fibroblast growth factor-23 signaling by klotho

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

energy reserve metabolic process

determination method

1 reference

14 February 2019

Disruption of klotho gene causes an abnormal energy homeostasis in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

glycosyl compound metabolic process

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35082&geneProductId=UniProtKB:O35082

determination method

carbohydrate metabolic process

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

acute inflammatory response

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

negative regulation of systemic arterial blood pressure

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

norepinephrine biosynthetic process

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35082

determination method

Glycosyl hydrolases family 1, N-terminal conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35082

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000077899

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000077899

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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