(Q14891894)

Aspartic peptidase domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Memapsin-like, protein family

1 reference

inferred from protein domain or family

Peptidase family A1 domain

1 reference

inferred from protein domain or family

Aspartic peptidase, active site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

endopeptidase activity

1 reference

9 August 2016

aspartic-type endopeptidase activity

English

1 reference

9 August 2016

4 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

4 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

3 references

endopeptidase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

aspartic-type endopeptidase activity

IDA

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

integral component of membrane

IBA

cell component

2 references

1 reference

16 September 2017

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

endoplasmic reticulum

1 reference

14 February 2019

cytoplasmic vesicle membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

3 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

5 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

4 references

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56818&geneProductId=UniProtKB:P56818

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Spatial segregation of gamma-secretase and substrates in distinct membrane domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

hippocampal mossy fiber to CA3 synapse

IDA

1 reference

14 February 2019

The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

amyloid-beta metabolic process

IDA

biological process

1 reference

9 August 2016

1 reference

9 August 2016

membrane protein ectodomain proteolysis

English

1 reference

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

7 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

membrane protein ectodomain proteolysis

IBA

3 references

1 reference

14 February 2019

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

TAS

response to radiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

regulation of synaptic plasticity

1 reference

14 February 2019

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

amyloid-beta metabolic process

TAS

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

modulation of chemical synaptic transmission

IBA

cellular response to copper ion

IGI

TAS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

cellular response to manganese ion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

cellular response to amyloid-beta

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

regulation of synaptic vesicle exocytosis

1 reference

14 February 2019

BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56818

Peptidase family A1 domain

IMP

has part(s)

1 reference

Aspartic peptidase, active site

1 reference

Memapsin-like

1 reference