(Q14901728)

English

Caveolin 3

mammalian protein found in Mus musculus

caveolin-3
Cav3
M-caveolin

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51637

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Caveolin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transmembrane transporter binding

determination method

5 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

protein binding

determination method

10 references

10 September 2018

Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

molecular adaptor activity

determination method

connexin binding

determination method

3 references

alpha-tubulin binding

determination method

1 reference

10 September 2018

Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy-1C

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

structural molecule activity

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

molecular adaptor activity

determination method

4 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

transmembrane transporter binding

determination method

6 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

connexin binding

determination method

4 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Connexin43 interacts with Caveolin-3 in the heart

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

4 references

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Sex differences in expression and subcellular localization of heart rhythm determinant proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

4 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 associates with developing T-tubules during muscle differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

12 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Neuregulin inhibits acetylcholine receptor aggregation in myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 associates with developing T-tubules during muscle differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

1 reference

10 September 2018

Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

Golgi apparatus

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

plasma membrane

determination method

8 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

12 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 deficiency causes muscle degeneration in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 associates with developing T-tubules during muscle differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

3 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

integral component of plasma membrane

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

13 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Neuregulin inhibits acetylcholine receptor aggregation in myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 associates with developing T-tubules during muscle differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Cardiac nitric oxide synthase-1 localization within the cardiomyocyte is accompanied by the adaptor protein, CAPON

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

protein-containing complex

determination method

3 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

13 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 deficiency causes muscle degeneration in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 associates with developing T-tubules during muscle differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

biological process

myotube differentiation

determination method

1 reference

10 September 2018

Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

muscle cell cellular homeostasis

determination method

4 references

10 September 2018

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 deficiency causes muscle degeneration in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

negative regulation of cardiac muscle hypertrophy

determination method

3 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

negative regulation of membrane depolarization during cardiac muscle cell action potential

determination method

1 reference

10 September 2018

Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of membrane potential

determination method

3 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

plasma membrane repair

determination method

1 reference

10 September 2018

Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of signaling

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

membrane raft organization

determination method

2 references

10 September 2018

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

cholesterol homeostasis

determination method

1 reference

10 September 2018

Insulin resistance in skeletal muscles of caveolin-3-null mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

triglyceride metabolic process

determination method

1 reference

10 September 2018

Insulin resistance in skeletal muscles of caveolin-3-null mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

heart trabecula formation

determination method

1 reference

10 September 2018

Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

glucose homeostasis

determination method

1 reference

10 September 2018

Insulin resistance in skeletal muscles of caveolin-3-null mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

actin filament organization

determination method

1 reference

10 September 2018

Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy-1C

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

cardiac muscle cell development

determination method

1 reference

10 September 2018

Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of branching involved in mammary gland duct morphogenesis

determination method

1 reference

10 September 2018

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

detection of muscle stretch

determination method

1 reference

10 September 2018

Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

cytoplasmic microtubule organization

determination method

1 reference

10 September 2018

Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy-1C

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of protein kinase B signaling

determination method

1 reference

10 September 2018

Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of p38MAPK cascade

determination method

1 reference

10 September 2018

Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

protein localization to plasma membrane

determination method

plasma membrane organization

determination method

3 references

10 September 2018

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 deficiency causes muscle degeneration in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

cell differentiation

determination method

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

negative regulation of protein kinase activity

determination method

1 reference

10 September 2018

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

nucleus localization

determination method

1 reference

10 September 2018

Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

negative regulation of MAPK cascade

determination method

1 reference

10 September 2018

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

myoblast fusion

determination method

1 reference

10 September 2018

Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy-1C

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

protein localization

determination method

5 references

10 September 2018

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

positive regulation of myotube differentiation

determination method

1 reference

10 September 2018

Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy-1C

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of calcium ion transport

determination method

1 reference

10 September 2018

Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

determination method

2 references

10 September 2018

The membrane-spanning domains of caveolins-1 and -2 mediate the formation of caveolin hetero-oligomers. Implications for the assembly of caveolae membranes in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

negative regulation of nitric-oxide synthase activity

determination method

1 reference

10 September 2018

Transgenic mice expressing mutant caveolin-3 show severe myopathy associated with increased nNOS activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

caveola assembly

determination method

4 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of transforming growth factor beta receptor signaling pathway

determination method

1 reference

10 September 2018

Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

negative regulation of calcium ion transport

determination method

3 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

cellular response to organonitrogen compound

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of membrane potential

determination method

4 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

caveola assembly

determination method

5 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

regulation of membrane depolarization during cardiac muscle cell action potential

determination method

3 references

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51637&geneProductId=UniProtKB:P51637

determination method

Caveolin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51637

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000074922

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000074922

Sitelinks

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