(Q14905130)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

2 references

integral component of membrane

3 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

2 references

2 references

2 references

1 reference

14 February 2019

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

3 references

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

IDA

endoplasmic reticulum

2 references

2 references

2 references

2 references

2 references

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

1 reference

14 February 2019

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

2 references

3 references

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

3 references

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

negative regulation of neuron apoptotic process

biological process

1 reference

14 February 2019

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

negative regulation of proteolysis

IDA

1 reference

14 February 2019

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

regulation of filopodium assembly

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

protein localization to membrane

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

positive regulation of protein phosphorylation

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

1 reference

14 February 2019

Behavioral assessment in mouse models of neuronal ceroid lipofuscinosis using a light-cued T-maze

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

negative regulation of catalytic activity

1 reference

14 February 2019

Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

neuromuscular process controlling balance

IDA

1 reference

14 February 2019

Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

ceramide metabolic process

cellular amino acid metabolic process

2 references

1 reference

14 February 2019

Altered amino acid levels in sera of a mouse model for juvenile neuronal ceroid lipofuscinoses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

neurotransmitter metabolic process

1 reference

14 February 2019

High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

1 reference

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

receptor-mediated endocytosis

lysosomal lumen pH elevation

2 references

globoside metabolic process

2 references

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

2 references

autophagosome maturation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

ionotropic glutamate receptor signaling pathway

1 reference

14 February 2019

Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

regulation of gene expression

1 reference

14 February 2019

Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

1 reference

14 February 2019

Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

membrane organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

protein localization to plasma membrane

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease)

lysosome organization

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

A murine model for juvenile NCL: gene targeting of mouse Cln3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

1 reference

14 February 2019

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

1 reference

14 February 2019

Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

actin cytoskeleton organization

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

sphingomyelin metabolic process

2 references

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

lysosomal lumen acidification

3 references

lysosome organization

5 references

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

A murine model for juvenile NCL: gene targeting of mouse Cln3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

regulation of intracellular pH

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124