(Q14905167)

http://www.ebi.ac.uk/interpro/protein/Q64429

Cytochrome P450 1B1

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64429

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

12 September 2018

1 reference

12 September 2018

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

monooxygenase activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

Specificity determinants of CYP1B1 estradiol hydroxylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

endoplasmic reticulum membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

endoplasmic reticulum

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

intrinsic apoptotic signaling pathway in response to oxidative stress

biological process

steroid metabolic process

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

nitric oxide biosynthetic process

1 reference

9 May 2019

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

blood vessel morphogenesis

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

estrogen metabolic process

collagen fibril organization

1 reference

9 May 2019

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

retina vasculature development in camera-type eye

1 reference

9 May 2019

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

retinol metabolic process

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

regulation of reactive oxygen species metabolic process

IDA

1 reference

9 May 2019

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

positive regulation of angiogenesis

1 reference

9 May 2019

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

retinal metabolic process

3 references

membrane lipid catabolic process

endothelial cell-cell adhesion

1 reference

9 May 2019

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

trabecular meshwork development

1 reference

9 May 2019

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

1 reference

9 May 2019

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

negative regulation of cell migration

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

dibenzo-p-dioxin metabolic process

1 reference

9 May 2019

For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

1 reference

9 May 2019

CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

retinal blood vessel morphogenesis

1 reference

9 May 2019

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

positive regulation of apoptotic process

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

xenobiotic metabolic process

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

positive regulation of vascular endothelial growth factor production

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

negative regulation of NF-kappaB transcription factor activity

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

arachidonic acid metabolic process

3 references

response to toxic substance

1 reference

9 May 2019

Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

negative regulation of cell adhesion mediated by integrin

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

endothelial cell migration

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

negative regulation of cell population proliferation

1 reference

9 May 2019

Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

cellular response to hydrogen peroxide

1 reference

9 May 2019

Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

cellular aromatic compound metabolic process

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia coli exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

Ah receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

9 May 2019

Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

positive regulation of smooth muscle cell migration

IDA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

benzene-containing compound metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

positive regulation of translation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

positive regulation of reactive oxygen species metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

positive regulation of DNA biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64429

cytochrome P450, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0