(Q14905477)

von Hippel-Lindau tumour suppressor protein

1 reference

VHL superfamily

1 reference

von Hippel-Lindau disease tumour suppressor, beta domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

von Hippel-Lindau disease tumour suppressor, beta domain, protein family

1 reference

inferred from protein domain or family

von Hippel-Lindau disease tumour suppressor, beta/alpha domain, protein family

1 reference

inferred from protein domain or family

von Hippel-Lindau disease tumour suppressor, alpha domain, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

1 reference

14 February 2019

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

protein-containing complex binding

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

Cul2-RING ubiquitin ligase complex

IEA

1 reference

14 February 2019

Regulation of ubiquitin ligase dynamics by the nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

1 reference

14 February 2019

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

1 reference

14 February 2019

Regulation of ubiquitin ligase dynamics by the nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40338&geneProductId=UniProtKB:P40338

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40338&geneProductId=UniProtKB:P40338

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40338&geneProductId=UniProtKB:P40338

24 April 2018

Regulation of ubiquitin ligase dynamics by the nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40338&geneProductId=UniProtKB:P40338

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

3 references

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

Regulation of ubiquitin ligase dynamics by the nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

IEA

glutamatergic synapse

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

homeostasis of number of retina cells

EXP

biological process

1 reference

14 February 2019

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

blood vessel endothelial cell migration

1 reference

14 February 2019

pVHL function is essential for endothelial extracellular matrix deposition.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

1 reference

14 February 2019

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

positive regulation of epithelial cell proliferation

1 reference

14 February 2019

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

regulation of thymocyte apoptotic process

1 reference

14 February 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

pancreatic A cell differentiation

IGI

1 reference

14 February 2019

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

extracellular matrix organization

1 reference

14 February 2019

pVHL function is essential for endothelial extracellular matrix deposition.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

negative regulation of endothelial cell differentiation

1 reference

14 February 2019

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

negative regulation of thymocyte apoptotic process

1 reference

14 February 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

ciliary body morphogenesis

1 reference

14 February 2019

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

melanin metabolic process

1 reference

14 February 2019

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

protein catabolic process

1 reference

14 February 2019

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

regulation of apoptotic signaling pathway

1 reference

14 February 2019

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

pVHL function is essential for endothelial extracellular matrix deposition.

IGI

protein ubiquitination

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

negative regulation of hypoxia-inducible factor-1alpha signaling pathway

1 reference

14 February 2019

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

regulation of gene expression

1 reference

14 February 2019

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

1 reference

14 February 2019

Regulation of ubiquitin ligase dynamics by the nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

proteasomal protein catabolic process

IDA

1 reference

14 February 2019

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

negative regulation of transcription from RNA polymerase II promoter in response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

type B pancreatic cell differentiation

IEA

1 reference

14 February 2019

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

NLS-bearing protein import into nucleus

1 reference

24 April 2018

Regulation of ubiquitin ligase dynamics by the nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P40338&geneProductId=UniProtKB:P40338

negative regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

negative regulation of receptor signaling pathway via JAK-STAT

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

regulation of postsynapse organization

3 references

14 February 2019

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

EXP

3 references

14 February 2019

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

14 February 2019

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40338

von Hippel-Lindau disease tumour suppressor, beta/alpha domain

EXP

has part(s)

1 reference

von Hippel-Lindau disease tumour suppressor, beta domain

1 reference

von Hippel-Lindau disease tumour suppressor, alpha domain

1 reference