(Q14907944)

Metallopeptidase, catalytic domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Peptidase M12B, ADAM/reprolysin, protein family

1 reference

ADAM10/ADAM17 catalytic domain, protein family

1 reference

ADAM17, membrane-proximal domain, protein family

1 reference

Disintegrin domain, protein family

1 reference

Peptidase M12B, propeptide family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

3 references

8 April 2019

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

serine-type endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

metallopeptidase activity

TAS

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

endopeptidase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

interleukin-6 receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

2 references

1 reference

27 February 2018

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

27 February 2018

Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

integral component of plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

biological process

Notch signaling pathway

1 reference

8 April 2019

positive regulation of transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

T cell differentiation in thymus

1 reference

8 April 2019

Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

germinal center formation

1 reference

8 April 2019

Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

production of molecular mediator involved in inflammatory response

1 reference

8 April 2019

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

regulation of mast cell apoptotic process

IDA

1 reference

8 April 2019

Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development

B cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

negative regulation of neuron projection development

1 reference

8 April 2019

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

regulation of axon regeneration

IGI

1 reference

8 April 2019

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

regulation of neuron migration

IGI

1 reference

8 April 2019

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

membrane protein ectodomain proteolysis

IGI

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

27 February 2018

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

27 February 2018

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

27 February 2018

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

Notch receptor processing

IDA

wound healing, spreading of epidermal cells

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

positive regulation of blood vessel endothelial cell migration

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

positive regulation of tumor necrosis factor-mediated signaling pathway

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

positive regulation of vascular endothelial cell proliferation

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0F8&geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

membrane protein ectodomain proteolysis

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

Metalloproteases regulate T-cell proliferation and effector function via LAG-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

8 April 2019

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

epidermal growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of T cell chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of cell growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

negative regulation of transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of chemokine production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

cell adhesion mediated by integrin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

receptor transactivation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of epidermal growth factor-activated receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

defense response to Gram-positive bacterium

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

cellular response to high density lipoprotein particle stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

negative regulation of cold-induced thermogenesis

1 reference

8 April 2019

Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of tumor necrosis factor-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of vascular endothelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

positive regulation of G1/S transition of mitotic cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0F8

Peptidase M12B, propeptide

has part(s)

1 reference

Peptidase M12B, ADAM/reprolysin

1 reference

Disintegrin domain

1 reference

ADAM17, membrane-proximal domain

1 reference

ADAM10/ADAM17 catalytic domain

1 reference