Wikidata

(Q14911756)

English

Cyclin-dependent kinase 4

mammalian protein found in Mus musculus

  • Cdk4
  • p34<PSK-J3>/cdk4
  • PSK-J3
  • serine/threonine kinase
  • CRK3
  • cell division protein kinase 4
  • cyclin-dependent kinase 4
In more languages

Statements

molecular function
protein binding
determination method
IPI
21 references
retrieved
14 February 2019
stated in
Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation
GOA
curator
UniProt
UniProt protein ID
P30285
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity
GOA
curator
UniProt
UniProt protein ID
P30285
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
CDK4 is an essential insulin effector in adipocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Isolation and characterization of cytoplasmic cyclin D1 mutants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Requirement for CDK4 kinase function in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
p53 family members in myogenic differentiation and rhabdomyosarcoma development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
retrieved
14 February 2019
stated in
The EGF receptor is required for efficient liver regeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
ISO
9 references
retrieved
24 April 2018
stated in
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
ISO
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P30285
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
IEA
retrieved
24 April 2018
stated in
Gene expression profile analysis of mouse colon embryonic development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
24 April 2018
stated in
C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
24 April 2018
stated in
Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
24 April 2018
stated in
CDK4 is an essential insulin effector in adipocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
24 April 2018
stated in
Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
24 April 2018
stated in
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P30285&geneProductId=UniProtKB:P30285
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISO
10 references
retrieved
14 February 2019
stated in
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P30285
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IEA
retrieved
14 February 2019
stated in
Gene expression profile analysis of mouse colon embryonic development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
14 February 2019
stated in
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
14 February 2019
stated in
C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
14 February 2019
stated in
Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
14 February 2019
stated in
Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
14 February 2019
stated in
CDK4 is an essential insulin effector in adipocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30285
determination method
IBA
biological process

Identifiers

 
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