(Q14912816)

http://www.ebi.ac.uk/interpro/protein/P48410

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48410

AAA proteins

1 reference

ABC transporter-like, protein family

1 reference

ABC transporter type 1, transmembrane domain, protein family

1 reference

ABC transporter, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

ATPase-coupled transmembrane transporter activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

ABC-type fatty-acyl-CoA transporter activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

1 reference

1 January 2018

A mitochondrial protein compendium elucidates complex I disease biology

GOA

curator

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease

GOA

curator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

endoplasmic reticulum

1 reference

9 May 2019

endoplasmic reticulum membrane

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

mitochondrial membranes

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

biological process

transmembrane transport

1 reference

9 May 2019

fatty acid beta-oxidation

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

1 January 2018

Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48410&geneProductId=UniProtKB:P48410

very long-chain fatty acid metabolic process

1 reference

9 May 2019

Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

regulation of oxidative phosphorylation

1 reference

9 May 2019

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

fatty acid beta-oxidation

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

fatty-acyl-CoA transport

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

Brain microsomal fatty acid elongation is increased in abcd1-deficient mouse during active myelination phase.

fatty acid elongation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

regulation of fatty acid beta-oxidation

4 references

9 May 2019

Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

A mouse model for X-linked adrenoleukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

positive regulation of fatty acid beta-oxidation

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Very long chain fatty acid β-oxidation in astrocytes: contribution of the ABCD1-dependent and -independent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

very long-chain fatty-acyl-CoA catabolic process

long-chain fatty acid catabolic process

very long-chain fatty acid catabolic process

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

regulation of mitochondrial depolarization

1 reference

9 May 2019

Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice

fatty acid homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

1 reference

9 May 2019

X-linked adrenoleukodystrophy mice demonstrate abnormalities in cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

negative regulation of cytokine production involved in inflammatory response

1 reference

9 May 2019

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

regulation of cellular response to oxidative stress

negative regulation of reactive oxygen species biosynthetic process

2 references

3 references

9 May 2019

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

9 May 2019

Astrocytes and mitochondria from adrenoleukodystrophy protein (ABCD1)-deficient mice reveal that the adrenoleukodystrophy-associated very long-chain fatty acids target several cellular energy-dependent functions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410

neuron projection maintenance

positive regulation of unsaturated fatty acid biosynthetic process

1 reference

9 May 2019

A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48410