(Q14914281)

http://www.ebi.ac.uk/interpro/protein/O35604

Niemann-Pick C1, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

lipid transporter activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

3 references

integral component of membrane

2 references

1 reference

14 February 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

1 reference

14 February 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

A molecular mechanism underlying the neural-specific defect in torsinA mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

late endosome membrane

1 reference

14 February 2019

1 reference

14 February 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

integral component of plasma membrane

3 references

1 reference

14 February 2019

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

perinuclear region of cytoplasm

endoplasmic reticulum

3 references

3 references

1 reference

14 February 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

integral component of lysosomal membrane

3 references

cellular response to steroid hormone stimulus

1 reference

14 February 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

steroid metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

1 reference

14 February 2019

Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

negative regulation of macroautophagy

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

bile acid metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

cellular response to low-density lipoprotein particle stimulus

ISS

cholesterol transport

3 references

1 reference

14 February 2019

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

cholesterol metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

protein glycosylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

viral entry into host cell

ISS

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.

cholesterol homeostasis

adult walking behavior

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

IGI

cholesterol homeostasis

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35604

intracellular cholesterol transport

3 references

Niemann-Pick C1, N-terminal

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35604

Sterol-sensing domain

1 reference

stated in

InterPro Release 71.0