(Q14914518)

English

Janus kinase 2

mammalian protein found in Mus musculus

Jak2
JAK-2
tyrosine-protein kinase JAK2

In more languages

Statements

1 reference

12 September 2018

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

tyrosine-protein kinase, non-receptor Jak2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

FERM superfamily, second domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Band 4.1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Janus kinase 2, pseudokinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Janus kinase 2, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

JAK2, FERM domain C-lobe, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase JAK2, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

FERM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

12 September 2018

UniProt protein ID

1 reference

12 September 2018

UniProt protein ID

molecular function

SH2 domain binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

kinase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

signaling receptor binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

interleukin-12 receptor binding

determination method

1 reference

9 May 2019

A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

histone kinase activity (H3-Y41 specific)

determination method

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

protein binding

determination method

14 references

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

A role for the ITAM signaling module in specifying cytokine-receptor functions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Differential biological activity of disease-associated JAK2 mutants

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

protein tyrosine kinase activity

determination method

9 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

nucleotide binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

identical protein binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

growth hormone receptor binding

determination method

protein C-terminus binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

type 1 angiotensin receptor binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

acetylcholine receptor binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

phosphatidylinositol 3-kinase binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

insulin receptor substrate binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

peptide hormone receptor binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

protein tyrosine kinase activity

determination method

15 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

determination method

4 references

9 May 2019

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

extrinsic component of cytoplasmic side of plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

determination method

1 reference

9 May 2019

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

determination method

1 reference

9 May 2019

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

endomembrane system

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

plasma membrane

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

glutamatergic synapse

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

biological process

myeloid cell differentiation

determination method

1 reference

9 May 2019

Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

adaptive immune response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

negative regulation of DNA binding

determination method

1 reference

9 May 2019

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

protein phosphorylation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

regulation of cell adhesion

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

9 May 2019

Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

negative regulation of cell population proliferation

determination method

1 reference

9 May 2019

Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

mammary gland epithelium development

determination method

1 reference

9 May 2019

Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

extrinsic apoptotic signaling pathway

determination method

1 reference

9 May 2019

Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

cytokine-mediated signaling pathway

determination method

4 references

24 April 2018

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Jak2 is essential for signaling through a variety of cytokine receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

determination method

1 reference

9 May 2019

Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

response to antibiotic

determination method

1 reference

9 May 2019

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of apoptotic signaling pathway

determination method

1 reference

9 May 2019

The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of tumor necrosis factor production

determination method

1 reference

9 May 2019

Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2019

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

cellular response to interleukin-3

determination method

1 reference

9 May 2019

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of growth hormone receptor signaling pathway

determination method

1 reference

9 May 2019

Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

cell differentiation

determination method

1 reference

9 May 2019

Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

phosphorylation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

immune system process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

post-embryonic hemopoiesis

determination method

1 reference

9 May 2019

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

negative regulation of apoptotic process

determination method

1 reference

9 May 2019

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

programmed cell death induced by symbiont

determination method

1 reference

9 May 2019

Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

cellular response to dexamethasone stimulus

determination method

1 reference

9 May 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

response to lipopolysaccharide

determination method

1 reference

9 May 2019

JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

peptidyl-tyrosine autophosphorylation

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

enzyme linked receptor protein signaling pathway

determination method

1 reference

9 May 2019

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

response to granulocyte macrophage colony-stimulating factor

determination method

1 reference

9 May 2019

Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

1 reference

9 May 2019

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

cellular response to lipopolysaccharide

determination method

1 reference

9 May 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

inflammatory response

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

positive regulation of tyrosine phosphorylation of STAT protein

determination method

activation of Janus kinase activity

determination method

1 reference

9 May 2019

Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

chromatin organization

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

regulation of receptor signaling pathway via JAK-STAT

determination method

1 reference

14 February 2019

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

receptor signaling pathway via JAK-STAT

determination method

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

14 February 2019

Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

14 February 2019

Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

14 February 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

14 February 2019

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

tyrosine phosphorylation of STAT protein

determination method

4 references

24 April 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

24 April 2018

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120

determination method

negative regulation of cardiac muscle cell apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

negative regulation of neuron apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of nitric-oxide synthase biosynthetic process

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

14 February 2019

Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

14 February 2019

Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

growth hormone receptor signaling pathway via JAK-STAT

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

negative regulation of cell death

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of growth factor dependent skeletal muscle satellite cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of epithelial cell apoptotic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of vascular associated smooth muscle cell proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

tyrosine phosphorylation of STAT protein

determination method

5 references

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

cytokine-mediated signaling pathway

determination method

5 references

9 May 2019

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Jak2 is essential for signaling through a variety of cytokine receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

erythrocyte differentiation

determination method

3 references

9 May 2019

Jak2 is essential for signaling through a variety of cytokine receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

innate immune response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

regulation of nitric oxide biosynthetic process

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

modulation of chemical synaptic transmission

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

postsynapse to nucleus signaling pathway

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of cold-induced thermogenesis

determination method

1 reference

9 May 2019

JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

microglial cell activation

determination method

1 reference

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

receptor signaling pathway via JAK-STAT

determination method

6 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of MHC class II biosynthetic process

determination method

1 reference

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

positive regulation of nitric-oxide synthase biosynthetic process

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

9 May 2019

Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

tyrosine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

Band 4.1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

Janus kinase 2, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

Janus kinase 2, pseudokinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

Tyrosine-protein kinase JAK2, SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

JAK2, FERM domain C-lobe

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62120

Identifiers

RefSeq protein ID

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

UniProt protein ID

1 reference

12 September 2018

UniProt protein ID

Ensembl protein ID

ENSMUSP00000025705

1 reference

ensembl Release 95

Ensembl protein ID

ENSMUSP00000025705

ENSMUSP00000064394

1 reference

ensembl Release 95

Ensembl protein ID

ENSMUSP00000064394

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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