(Q15331919)

Protein kinase-like domain superfamily

1 reference

SH2 domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase Lyn, SH3 domain, protein family

1 reference

SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

Tyrosine-protein kinase Lyn, SH2 domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

erythropoietin receptor binding

1 reference

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

protein binding

10 references

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Leupaxin negatively regulates B cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Gab3, a new DOS/Gab family member, facilitates macrophage differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

8 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

24 April 2018

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

24 April 2018

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

24 April 2018

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

protein-containing complex binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

9 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Involvement of the Src kinase Lyn in phospholipase C-gamma 2 phosphorylation and phosphatidylinositol 3-kinase activation in Epo signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

signaling receptor binding

EXP

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

extrinsic component of cytoplasmic side of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

perinuclear region of cytoplasm

nucleus

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

Golgi apparatus

plasma membrane

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

mast cell granule

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

membrane

membrane raft

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

cellular response to extracellular stimulus

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

positive regulation of B cell receptor signaling pathway

IGI

1 reference

14 February 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

tolerance induction to self antigen

IGI

1 reference

24 April 2018

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

regulation of mast cell activation

1 reference

8 April 2019

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

cellular response to heat

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

response to amino acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

regulation of erythrocyte differentiation

1 reference

8 April 2019

Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

cellular response to DNA damage stimulus

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

protein phosphorylation

regulation of B cell apoptotic process

1 reference

24 April 2018

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

positive regulation of dendritic cell apoptotic process

1 reference

24 April 2018

The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

hemoglobin biosynthetic process

1 reference

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

neuron projection development

1 reference

24 April 2018

Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

response to carbohydrate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

regulation of platelet aggregation

1 reference

24 April 2018

An important role of the SRC family kinase Lyn in stimulating platelet granule secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

negative regulation of cell population proliferation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

B cell receptor signaling pathway

1 reference

14 February 2019

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

negative regulation of myeloid leukocyte differentiation

1 reference

8 April 2019

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

dendritic cell differentiation

1 reference

24 April 2018

Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

Fc receptor mediated inhibitory signaling pathway

1 reference

8 April 2019

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

transmembrane receptor protein tyrosine kinase signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

regulation of B cell receptor signaling pathway

1 reference

24 April 2018

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

response to sterol depletion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

regulation of cytokine production

1 reference

8 April 2019

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

response to insulin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

negative regulation of MAP kinase activity

1 reference

8 April 2019

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

erythrocyte differentiation

1 reference

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

protein autophosphorylation

Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

regulation of mast cell degranulation

1 reference

24 April 2018

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

oligodendrocyte development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

response to toxic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

negative regulation of protein phosphorylation

1 reference

8 April 2019

The Src kinase Lyn is a negative regulator of mast cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

Fc receptor mediated stimulatory signaling pathway

1 reference

24 April 2018

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

B cell homeostasis

1 reference

8 April 2019

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

immune response-regulating cell surface receptor signaling pathway

1 reference

8 April 2019

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

response to axon injury

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

negative regulation of mast cell proliferation

1 reference

24 April 2018

The Src kinase Lyn is a negative regulator of mast cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

regulation of inflammatory response

1 reference

8 April 2019

Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

peptidyl-tyrosine autophosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

response to hormone

1 reference

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

intracellular signal transduction

1 reference

8 April 2019

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

negative regulation of intracellular signal transduction

1 reference

8 April 2019

The Src kinase Lyn is a negative regulator of mast cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

positive regulation of cell migration

1 reference

8 April 2019

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

negative regulation of toll-like receptor 2 signaling pathway

1 reference

8 April 2019

Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

response to peptide hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

platelet degranulation

1 reference

24 April 2018

An important role of the SRC family kinase Lyn in stimulating platelet granule secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

positive regulation of phosphatidylinositol 3-kinase activity

1 reference

8 April 2019

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

positive regulation of cell population proliferation

negative regulation of ERK1 and ERK2 cascade

peptidyl-tyrosine phosphorylation

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

negative regulation of B cell proliferation

1 reference

24 April 2018

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

negative regulation of toll-like receptor 4 signaling pathway

1 reference

8 April 2019

Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

signal transduction

1 reference

8 April 2019

HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

1 reference

24 April 2018

central nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25911&geneProductId=UniProtKB:P25911

1 reference

24 April 2018

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

1 reference

8 April 2019

hemopoiesis

1 reference

8 April 2019

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

regulation of release of sequestered calcium ion into cytosol

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

Fc receptor mediated stimulatory signaling pathway

tolerance induction to self antigen

regulation of B cell apoptotic process

cell differentiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25911

negative regulation of B cell proliferation

regulation of mast cell degranulation

regulation of B cell receptor signaling pathway

regulation of platelet aggregation

dendritic cell differentiation

positive regulation of dendritic cell apoptotic process

tyrosine-protein kinase, active site

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

SH3 domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

protein kinase domain

1 reference

SH2 domain

1 reference

Tyrosine-protein kinase Lyn, SH2 domain

1 reference

Tyrosine-protein kinase Lyn, SH3 domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016