(Q1759126)

English

Lacritin

mammalian protein found in Homo sapiens

LACRT
extracellular glycoprotein lacritin

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Extracellular glycoprotein lacritin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZZ8

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

laminin-1 binding

determination method

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

fibronectin binding

determination method

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

growth factor activity

determination method

1 reference

8 April 2019

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

collagen binding

determination method

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

protein N-terminus binding

determination method

1 reference

8 April 2019

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

protein binding

determination method

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

secretory granule

determination method

1 reference

17 October 2017

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ8&geneProductId=UniProtKB:Q9GZZ8

determination method

extracellular space

determination method

2 references

extracellular region

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

extracellular space

determination method

biological process

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

calcineurin-NFAT signaling cascade

determination method

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

positive regulation of release of sequestered calcium ion into cytosol

determination method

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

calcium-mediated signaling

determination method

positive regulation of epithelial cell proliferation

determination method

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

protein localization to Golgi apparatus

determination method

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

epithelial structure maintenance

determination method

1 reference

8 April 2019

Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

protein acetylation

determination method

1 reference

8 April 2019

Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

positive regulation of cell population proliferation

determination method

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ8&geneProductId=UniProtKB:Q9GZZ8

determination method

17 October 2017

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ8&geneProductId=UniProtKB:Q9GZZ8

determination method

17 October 2017

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ8&geneProductId=UniProtKB:Q9GZZ8

determination method

positive regulation of epithelial cell proliferation involved in wound healing

determination method

1 reference

8 April 2019

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

positive regulation of macroautophagy

determination method

1 reference

8 April 2019

Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

determination method

4 references

8 April 2019

Lacritin and other new proteins of the lacrimal functional unit

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

A thermo-responsive protein treatment for dry eyes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

negative regulation of lipopolysaccharide-mediated signaling pathway

determination method

1 reference

8 April 2019

Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

positive regulation of calcium-mediated signaling

determination method

1 reference

8 April 2019

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

defense response to bacterium

determination method

1 reference

8 April 2019

A cleavage-potentiated fragment of tear lacritin is bactericidal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

positive regulation of cell population proliferation

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

calcium-mediated signaling

determination method

3 references

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

positive regulation of secretion

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

positive regulation of calcineurin-NFAT signaling cascade

determination method

1 reference

8 April 2019

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ8

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000257867

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000257867

ENSP00000447536

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447536

ENSP00000448193

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448193

0 references

Microsoft Academic ID

0 references

Sitelinks

Wikipedia(4 entries)

dewiki Lacritin
enwiki Lacritin
ttwiki LACRT
ukwiki LACRT

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q1759126&oldid=2022903419"