(Q21096456)

English

Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

mammalian protein found in Homo sapiens

signaling adaptor protein DIP13alpha
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
adapter protein containing PH domain, PTB domain and leucine zipper motif 1
dip13-alpha
AKT2 interactor
APPL1
adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
DCC-interacting protein 13-alpha

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein kinase B binding

determination method

1 reference

17 October 2017

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

protein binding

determination method

22 references

8 April 2019

Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Mediation of the DCC apoptotic signal by DIP13 alpha

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

A quantitative protein interaction network for the ErbB receptors using protein microarrays

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Phospho-tyrosine dependent protein-protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

The functional interactome landscape of the human histone deacetylase family

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

identical protein binding

determination method

3 references

17 October 2017

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

17 October 2017

Crystal structures of the BAR-PH and PTB domains of human APPL1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

17 October 2017

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

phosphatidylserine binding

determination method

1 reference

8 April 2019

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

phosphatidylinositol binding

determination method

1 reference

8 April 2019

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

identical protein binding

determination method

4 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Crystal structures of the BAR-PH and PTB domains of human APPL1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

protein-containing complex binding

determination method

1 reference

8 April 2019

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

beta-tubulin binding

determination method

1 reference

8 April 2019

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

determination method

1 reference

17 October 2017

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

determination method

1 reference

17 October 2017

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

determination method

1 reference

8 April 2019

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

early endosome membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

vesicle membrane

determination method

1 reference

8 April 2019

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

extracellular exosome

determination method

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

determination method

determination method

3 references

14 January 2019

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

14 January 2019

Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

14 January 2019

Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

plasma membrane

determination method

1 reference

8 April 2019

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

endosome membrane

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

cytoplasmic vesicle

determination method

1 reference

14 January 2019

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKG1&geneProductId=UniProtKB:Q9UKG1

determination method

extracellular exosome

determination method

intracellular vesicle

determination method

1 reference

8 April 2019

Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

cell projection

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

phagocytic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

biological process

regulation of glucose import

determination method

1 reference

8 April 2019

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

cell population proliferation

determination method

1 reference

8 April 2019

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

signal transduction

determination method

1 reference

8 April 2019

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

regulation of protein localization to plasma membrane

determination method

1 reference

8 April 2019

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

insulin receptor signaling pathway

determination method

3 references

8 April 2019

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Loss-of-Function Mutations in APPL1 in Familial Diabetes Mellitus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

adiponectin-activated signaling pathway

determination method

1 reference

8 April 2019

Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

positive regulation of glucose import

determination method

1 reference

8 April 2019

The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

positive regulation of melanin biosynthetic process

determination method

1 reference

8 April 2019

Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

protein import into nucleus

determination method

1 reference

8 April 2019

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKG1

determination method

http://purl.uniprot.org/uniprot/Q9UKG1

1 reference

Identifiers.org

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKG1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKG1

APPL1, BAR domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKG1

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000288266

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000288266

ENSP00000406095

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000406095

ENSP00000419644

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419644

ENSP00000498115

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498115

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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