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(Q21100305)
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BCL2 like 10
mammalian protein found in Homo sapiens
death inducer binding to vBcl-2 and Apaf-1
anti-apoptotic protein NrH
apoptosis regulator Bcl-B
bcl-2-like protein 10
BCL2-like 10 (apoptosis facilitator)
BCL2L10
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9HD36
part of
Blc2-like superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9HD36
Bcl-2 family
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9HD36
Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9HD36
encoded by
BCL2L10
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9HD36
molecular function
protein binding
determination method
IPI
3 references
retrieved
8 April 2019
stated in
HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IPI
retrieved
8 April 2019
stated in
The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IPI
retrieved
8 April 2019
stated in
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IPI
caspase binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IPI
protein homodimerization activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IBA
protein heterodimerization activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IBA
cell component
nucleus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HD36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IEA
integral component of membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HD36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IEA
cytosol
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IDA
nuclear membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HD36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IEA
mitochondrion
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HD36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IEA
retrieved
8 April 2019
stated in
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IDA
membrane
determination method
TAS
IEA
2 references
retrieved
8 April 2019
stated in
Boo, a novel negative regulator of cell death, interacts with Apaf-1.
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HD36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IEA
mitochondrial outer membrane
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IBA
biological process
apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9HD36
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IEA
regulation of apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IEA
negative regulation of apoptotic process
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IDA
activation of cysteine-type endopeptidase activity involved in apoptotic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
TAS
female gamete generation
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Boo, a novel negative regulator of cell death, interacts with Apaf-1.
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
TAS
spermatogenesis
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Boo, a novel negative regulator of cell death, interacts with Apaf-1.
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
TAS
intrinsic apoptotic signaling pathway in response to DNA damage
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IBA
extrinsic apoptotic signaling pathway in absence of ligand
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HD36
determination method
IBA
negative regulation of intrinsic apoptotic signaling pathway
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HD36&geneProductId=UniProtKB:Q9HD36
determination method
IBA
has part(s)
Apoptosis regulator, Bcl-2, BH2 motif, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9HD36
Apoptosis regulator, Bcl-2, BH1 motif, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9HD36
Identifiers
RefSeq protein ID
NP_001293097
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10017
NP_065129
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
10017
UniProt protein ID
Q9HD36
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9HD36
Ensembl protein ID
ENSP00000260442
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000260442
ENSP00000453562
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000453562
PDB structure ID
4B4S
1 reference
stated in
UniProt
UniProt protein ID
Q9HD36
retrieved
20 March 2016
language of work or name
English
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