Wikidata

(Q21100486)

English

RB binding protein 8, endonuclease

mammalian protein found in Homo sapiens

  • RIM
  • RBBP-8
  • Retinoblastoma-interacting protein and myosin-like
  • CTBP-interacting protein
  • retinoblastoma binding protein 8
  • CtIP
  • SAE2
  • sporulation in the absence of SPO11 protein 2 homolog
  • RBBP8
  • DNA endonuclease RBBP8
  • Retinoblastoma-binding protein 8
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
20 references
retrieved
8 April 2019
stated in
Human SIRT6 promotes DNA end resection through CtIP deacetylation
GOA
curator
UniProt
UniProt protein ID
Q99708
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity
GOA
curator
UniProt
UniProt protein ID
Q99708
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
EXD2 promotes homologous recombination by facilitating DNA end resection
GOA
curator
UniProt
UniProt protein ID
Q99708
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair
GOA
curator
UniProt
UniProt protein ID
Q99708
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
GOA
curator
UniProt
UniProt protein ID
Q99708
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
GOA
curator
UniProt
UniProt protein ID
Q99708
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
CDK targets Sae2 to control DNA-end resection and homologous recombination
GOA
curator
UniProt
UniProt protein ID
Q99708
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.
GOA
curator
UniProt
UniProt protein ID
Q99708
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
EXD2 promotes homologous recombination by facilitating DNA end resection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of a carboxy-terminal BRCA1 interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
CtIP tetramer assembly is required for DNA-end resection and repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
LEDGF (p75) promotes DNA-end resection and homologous recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
retrieved
8 April 2019
stated in
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99708
determination method or standard
IPI
cell component
biological process

Identifiers

 
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