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Caspase 12 (gene/pseudogene)
mammalian protein found in Homo sapiens
CASP12
caspase 12 pseudogene 1
inactive caspase-12
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q6UXS9
part of
caspase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXS9
caspase 12
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXS9
Death-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXS9
Peptidase C14, caspase non-catalytic subunit p10, protein family
1 reference
based on heuristic
inferred from protein domain or family
Peptidase family C14A, cysteine active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
CARD domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Peptidase C14, p20 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Peptidase C14A, caspase catalytic domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q6UXS9
encoded by
CASP12
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q6UXS9
molecular function
cysteine-type endopeptidase activity involved in apoptotic process
determination method
IKR
1 reference
retrieved
21 June 2018
stated in
Human caspase 12 has acquired deleterious mutations
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6UXS9&geneProductId=UniProtKB:Q6UXS9
determination method
IKR
cysteine-type peptidase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IEA
cysteine-type endopeptidase activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IBA
cysteine-type endopeptidase activity involved in apoptotic process
determination method
IBA
IKR
2 references
retrieved
8 April 2019
stated in
Human caspase 12 has acquired deleterious mutations
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IKR
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IBA
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IBA
cell component
NLRP3 inflammasome complex
determination method
IBA
1 reference
retrieved
21 June 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6UXS9&geneProductId=UniProtKB:Q6UXS9
determination method
IBA
AIM2 inflammasome complex
determination method
IBA
1 reference
retrieved
21 June 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6UXS9&geneProductId=UniProtKB:Q6UXS9
determination method
IBA
IPAF inflammasome complex
determination method
IBA
1 reference
retrieved
21 June 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6UXS9&geneProductId=UniProtKB:Q6UXS9
determination method
IBA
endoplasmic reticulum
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IDA
cytoplasm
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IBA
biological process
regulation of apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IEA
regulation of inflammatory response
determination method
IBA
1 reference
retrieved
21 June 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6UXS9&geneProductId=UniProtKB:Q6UXS9
determination method
IBA
proteolysis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IEA
execution phase of apoptosis
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IBA
apoptotic process
determination method
IEA
1 reference
retrieved
21 June 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6UXS9&geneProductId=UniProtKB:Q6UXS9
determination method
IEA
apoptotic process
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IBA
activation of cysteine-type endopeptidase activity involved in apoptotic process
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IBA
apoptotic signaling pathway
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6UXS9
determination method
IEA
physically interacts with
emricasan
object has role
reaction inhibitor
1 reference
stated in
Open Targets Platform
retrieved
14 August 2023
reference URL
https://platform.opentargets.org/drug/CHEMBL197672
has part(s)
Peptidase C14, p20 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXS9
Peptidase C14A, caspase catalytic domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXS9
Peptidase C14, caspase non-catalytic subunit p10
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXS9
CARD domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXS9
Peptidase family C14A, cysteine active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q6UXS9
Identifiers
RefSeq protein ID
NP_001177945
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
100506742
UniProt protein ID
Q6UXS9
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q6UXS9
Ensembl protein ID
ENSP00000421408
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000421408
ENSP00000424038
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000424038
ENSP00000424963
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000424963
ENSP00000426566
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000426566
ENSP00000427128
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000427128
ENSP00000421815
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000421815
ENSP00000423899
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000423899
ENSP00000423970
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000423970
ENSP00000425652
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000425652
ENSP00000426427
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000426427
ENSP00000427437
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000427437
ENSP00000482745
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000482745
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