(Q21100641)

English

F-box protein 5

mammalian protein found in Homo sapiens

F-box protein Fbx5
early mitotic inhibitor 1
FBXO5
F-box only protein 5

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

protein binding

determination method

7 references

8 April 2019

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

ubiquitin ligase inhibitor activity

determination method

1 reference

8 April 2019

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

biological process

vesicle organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

regulation of meiotic nuclear division

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

microtubule polymerization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

regulation of transcription involved in G1/S transition of mitotic cell cycle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

spindle assembly

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

oocyte maturation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

spindle assembly involved in female meiosis I

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

regulation of mitotic nuclear division

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKT4&geneProductId=UniProtKB:Q9UKT4

determination method

negative regulation of ubiquitin protein ligase activity

determination method

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKT4&geneProductId=UniProtKB:Q9UKT4

determination method

anaphase-promoting complex-dependent catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

negative regulation of mitotic metaphase/anaphase transition

determination method

negative regulation of ubiquitin protein ligase activity

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

The APC/C inhibitor, Emi1, is essential for prevention of rereplication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

positive regulation of G2/M transition of mitotic cell cycle

determination method

1 reference

8 April 2019

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

negative regulation of DNA endoreduplication

determination method

1 reference

8 April 2019

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

positive regulation of osteoblast differentiation

determination method

1 reference

8 April 2019

Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

negative regulation of ubiquitin-protein transferase activity

determination method

1 reference

8 April 2019

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

positive regulation of biomineral tissue development

determination method

1 reference

8 April 2019

Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

negative regulation of ubiquitin protein ligase activity

determination method

4 references

8 April 2019

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

8 April 2019

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

positive regulation of mesenchymal stem cell migration

determination method

1 reference

8 April 2019

Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

negative regulation of cellular senescence

determination method

1 reference

8 April 2019

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

negative regulation of response to DNA damage stimulus

determination method

1 reference

8 April 2019

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

protein ubiquitination

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

regulation of mitotic cell cycle phase transition

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UKT4

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000229758

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000229758

ENSP00000356210

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356210

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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