(Q21100641)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

IPI

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

ubiquitin ligase inhibitor activity

IPI

1 reference

8 April 2019

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

regulation of meiotic nuclear division

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

microtubule polymerization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

regulation of transcription involved in G1/S transition of mitotic cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

spindle assembly involved in female meiosis I

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

regulation of mitotic nuclear division

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKT4&geneProductId=UniProtKB:Q9UKT4

negative regulation of ubiquitin protein ligase activity

IBA

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UKT4&geneProductId=UniProtKB:Q9UKT4

anaphase-promoting complex-dependent catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

negative regulation of mitotic metaphase/anaphase transition

TAS

negative regulation of ubiquitin protein ligase activity

positive regulation of cell population proliferation

1 reference

8 April 2019

The APC/C inhibitor, Emi1, is essential for prevention of rereplication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

positive regulation of G2/M transition of mitotic cell cycle

1 reference

8 April 2019

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

negative regulation of DNA endoreduplication

1 reference

8 April 2019

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

positive regulation of osteoblast differentiation

1 reference

8 April 2019

Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

negative regulation of ubiquitin-protein transferase activity

1 reference

8 April 2019

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

positive regulation of biomineral tissue development

1 reference

8 April 2019

Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

negative regulation of ubiquitin protein ligase activity

4 references

8 April 2019

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

8 April 2019

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

positive regulation of mesenchymal stem cell migration

1 reference

8 April 2019

Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

negative regulation of cellular senescence

1 reference

8 April 2019

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

negative regulation of response to DNA damage stimulus

1 reference

8 April 2019

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

protein ubiquitination

1 reference

8 April 2019

regulation of mitotic cell cycle phase transition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKT4

1 reference

InterPro Release 71.0