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Rho guanine nucleotide exchange factor 16
mammalian protein found in Homo sapiens
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
ephexin4
Rho guanine exchange factor (GEF) 16
rho guanine nucleotide exchange factor 16
ephexin-4
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q5VV41
part of
SH3-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q5VV41
Dbl homology (DH) domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q5VV41
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q5VV41
pleckstrin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
ARHGEF16/ARHGEF26, SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Dbl homology (DH) domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q5VV41
encoded by
ARHGEF16
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q5VV41
molecular function
receptor tyrosine kinase binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
Q5VV41
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IPI
PDZ domain binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IPI
protein binding
determination method
IPI
3 references
retrieved
8 April 2019
stated in
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
Q5VV41
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IPI
retrieved
8 April 2019
stated in
Proteome-wide analysis of phospho-regulated PDZ domain interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IPI
guanyl-nucleotide exchange factor activity
determination method
IEA
TAS
2 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5VV41&geneProductId=UniProtKB:Q5VV41
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q5VV41
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5VV41&geneProductId=UniProtKB:Q5VV41
determination method
IEA
cadherin binding
determination method
IDA
1 reference
retrieved
31 October 2017
stated in
E-cadherin interactome complexity and robustness resolved by quantitative proteomics
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5VV41&geneProductId=UniProtKB:Q5VV41
determination method
IDA
cadherin binding
determination method
HDA
1 reference
retrieved
8 April 2019
stated in
E-cadherin interactome complexity and robustness resolved by quantitative proteomics
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
HDA
guanyl-nucleotide exchange factor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q5VV41
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IEA
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q5VV41
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IEA
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
TAS
biological process
cell chemotaxis
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
Q5VV41
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IMP
regulation of Rho protein signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IEA
regulation of small GTPase mediated signal transduction
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
TAS
activation of GTPase activity
determination method
IDA
IMP
2 references
retrieved
8 April 2019
stated in
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
Q5VV41
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IMP
retrieved
8 April 2019
stated in
The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IDA
positive regulation of apoptotic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
TAS
positive regulation of protein localization to plasma membrane
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
Q5VV41
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
IMP
G protein-coupled receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5VV41
determination method
TAS
has part(s)
pleckstrin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q5VV41
Dbl homology (DH) domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q5VV41
SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q5VV41
ARHGEF16/ARHGEF26, SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q5VV41
Identifiers
RefSeq protein ID
NP_055263
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
27237
XP_016856538
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
27237
XP_016856539
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
27237
XP_016856540
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
27237
XP_024302222
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
27237
XP_024302223
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
27237
UniProt protein ID
Q5VV41
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q5VV41
Ensembl protein ID
ENSP00000367622
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000367622
ENSP00000367624
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000367624
ENSP00000367629
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000367629
ENSP00000390853
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000390853
ENSP00000411936
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000411936
PDB structure ID
1X6B
1 reference
stated in
UniProt
UniProt protein ID
Q5VV41
retrieved
4 August 2016
language of work or name
English
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