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(Q21101977)
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Rho guanine nucleotide exchange factor 19
mammalian protein found in Homo sapiens
weakly similar to Rho GEF
Rho guanine nucleotide exchange factor (GEF) 19
rho guanine nucleotide exchange factor 19
ephexin2
ARHGEF19
ephexin-2
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8IW93
part of
SH3-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IW93
Dbl homology (DH) domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IW93
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IW93
pleckstrin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Dbl homology (DH) domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
SH3 domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8IW93
encoded by
ARHGEF19
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8IW93
molecular function
GTPase activator activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IW93
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
IEA
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
IPI
guanyl-nucleotide exchange factor activity
determination method
IEA
TAS
2 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IW93&geneProductId=UniProtKB:Q8IW93
determination method
TAS
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IW93
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IW93&geneProductId=UniProtKB:Q8IW93
determination method
IEA
guanyl-nucleotide exchange factor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q8IW93
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
IEA
cell component
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
TAS
biological process
wound healing
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
IEA
Wnt signaling pathway, planar cell polarity pathway
determination method
NAS
1 reference
retrieved
8 April 2019
stated in
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
NAS
regulation of actin cytoskeleton organization
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
Epidermal wound repair is regulated by the planar cell polarity signaling pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
IGI
regulation of Rho protein signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
IEA
positive regulation of GTPase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
IEA
positive regulation of apoptotic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
TAS
regulation of small GTPase mediated signal transduction
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
TAS
G protein-coupled receptor signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IW93
determination method
TAS
has part(s)
SH3 domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IW93
pleckstrin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IW93
Dbl homology (DH) domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q8IW93
Identifiers
RefSeq protein ID
NP_694945
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
128272
XP_011539008
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
128272
UniProt protein ID
Q8IW93
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q8IW93
Ensembl protein ID
ENSP00000270747
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000270747
ENSP00000391145
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000391145
ENSP00000414370
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000414370
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