Wikidata

(Q21102029)

English

CD247 molecule

mammalian protein found in Homo sapiens

  • CD247
  • T-cell receptor T3 zeta chain
  • T-cell antigen receptor complex, zeta subunit of CD3
  • TCR zeta chain
  • CD3zeta chain
  • T-cell surface glycoprotein CD3 zeta chain
  • CD247 antigen, zeta subunit
  • CD3Z antigen, zeta polypeptide (TiT3 complex)
In more languages

Statements

molecular function
protein binding
determination method
IPI
19 references
retrieved
8 April 2019
stated in
BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
GOA
curator
UniProt
UniProt protein ID
P20963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling
GOA
curator
UniProt
UniProt protein ID
P20963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70
GOA
curator
UniProt
UniProt protein ID
P20963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
GOA
curator
UniProt
UniProt protein ID
P20963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.
GOA
curator
UniProt
UniProt protein ID
P20963
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
End-binding protein 1 controls signal propagation from the T cell receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of activation for Zap-70 catalytic activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
The adaptor protein SAP directly associates with CD3ζ chain and regulates T cell receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
Alternative modes of binding of proteins with tandem SH2 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
Peptide microarrays for the detection of molecular interactions in cellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
retrieved
8 April 2019
stated in
Identification of substrates of human protein-tyrosine phosphatase PTPN22
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20963
determination method
IPI
cell component
biological process

Identifiers

 
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