(Q21103082)

http://www.ebi.ac.uk/interpro/protein/Q12891

glycoside hydrolase superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12891

TIM barrel

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q12891

1 reference

13 November 2019

1 reference

13 November 2019

hyaluronoglucuronidase activity

1 reference

8 April 2019

Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

hyalurononglucosaminidase activity

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Hyaluronidases and CD44 undergo differential modulation during chondrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

receptor tyrosine kinase binding

1 reference

8 April 2019

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

hydrolase activity, acting on glycosyl bonds

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

3 references

8 April 2019

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

IPI

hyaluronic acid binding

receptor signaling protein tyrosine kinase inhibitor activity

1 reference

8 April 2019

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

anchored component of plasma membrane

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

2 references

1 reference

8 April 2019

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

anchored component of external side of plasma membrane

NAS

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

perinuclear region of cytoplasm

1 reference

8 April 2019

Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

anchored component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

negative regulation of protein kinase B signaling

1 reference

8 April 2019

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

negative regulation of fibroblast migration

1 reference

8 April 2019

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

positive regulation of inflammatory response

1 reference

8 April 2019

Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

hyaluronan catabolic process

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

8 April 2019

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

positive regulation of urine volume

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

response to reactive oxygen species

1 reference

8 April 2019

Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

Hyaluronidases and CD44 undergo differential modulation during chondrogenesis

response to antibiotic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

cellular response to tumor necrosis factor

IEP

1 reference

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

skeletal system morphogenesis

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

cellular response to fibroblast growth factor stimulus

1 reference

8 April 2019

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

multicellular organismal iron ion homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

Hyaluronidases and CD44 undergo differential modulation during chondrogenesis

cartilage development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

negative regulation of protein tyrosine kinase activity

IEP

1 reference

8 April 2019

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

cellular response to UV-B

1 reference

8 April 2019

Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

glycosaminoglycan catabolic process

1 reference

8 April 2019

HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

negative regulation of MAP kinase activity

1 reference

8 April 2019

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

negative regulation of cell growth

1 reference

8 April 2019

HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

hematopoietic progenitor cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

multicellular organism aging

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

cellular response to interleukin-1

1 reference

8 April 2019

Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

renal water absorption

1 reference

8 April 2019

defense response to virus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

viral entry into host cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

carbohydrate metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

transformation of host cell by virus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891

transcription by RNA polymerase II

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12891&geneProductId=UniProtKB:Q12891