Wikidata

(Q21104738)

English

Neutrophil cytosolic factor 1

mammalian protein found in Homo sapiens

  • nox-organizing protein 2
  • neutrophil NADPH oxidase factor 1
  • nox organizer 2
  • NCF1
  • NCF-47K
  • SH3 and PX domain-containing protein 1A
  • 47 kDa autosomal chronic granulomatous disease protein
  • NCF-1
  • NADPH oxidase organizer 2
  • neutrophil cytosol factor 1
  • 47 kDa neutrophil oxidase factor
  • neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
  • p47-phox
In more languages

Statements

molecular function
protein binding
determination method
IPI
12 references
retrieved
8 April 2019
stated in
Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinase
GOA
curator
UniProt
UniProt protein ID
P14598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
Activation state-dependent interaction between Galphai and p67phox
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
Induction of colonic epithelial cell apoptosis by p47-dependent oxidants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
A region C-terminal to the proline-rich core of p47phox regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67phox
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
Identification of an actin-binding site in p47phox an organizer protein of NADPH oxidase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
Novel PKC-ζ to p47 phox interaction is necessary for transformation from blebbishields
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
retrieved
8 April 2019
stated in
Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking"
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IPI
cell component
cytosol
determination method
IDA
TAS
IEA
6 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14598&geneProductId=UniProtKB:P14598
determination method
TAS
retrieved
5 June 2018
stated in
Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14598&geneProductId=UniProtKB:P14598
determination method
TAS
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P14598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14598&geneProductId=UniProtKB:P14598
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14598&geneProductId=UniProtKB:P14598
determination method
IEA
retrieved
5 June 2018
stated in
Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase
GOA
curator
UniProt
UniProt protein ID
P14598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14598&geneProductId=UniProtKB:P14598
determination method
IDA
retrieved
5 June 2018
stated in
Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P14598&geneProductId=UniProtKB:P14598
determination method
IDA
cytosol
determination method
IBA
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
TAS
retrieved
8 April 2019
stated in
Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P14598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IEA
retrieved
8 April 2019
stated in
Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase
GOA
curator
UniProt
UniProt protein ID
P14598
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IDA
retrieved
8 April 2019
stated in
Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14598
determination method
IBA
biological process

Identifiers

 
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