Wikidata

(Q21104745)

English

RAS p21 protein activator 1

mammalian protein found in Homo sapiens

  • Ras p21 protein activator
  • p120GAP
  • ras GTPase-activating protein 1
  • RASA1
  • RAS p21 protein activator (GTPase activating protein) 1
  • triphosphatase-activating protein
  • p120 RAS GTPase activating protein
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No label defined

No description defined

Statements

part of
molecular function
protein binding
determination method or standard
IPI
19 references
retrieved
1 January 2018
stated in
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
GOA
curator
UniProt
UniProt protein ID
P20936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells
GOA
curator
UniProt
UniProt protein ID
P20936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region
GOA
curator
UniProt
UniProt protein ID
P20936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
GOA
curator
UniProt
UniProt protein ID
P20936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
A Ras-GTPase-activating protein SH3-domain-binding protein
GOA
curator
UniProt
UniProt protein ID
P20936
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Charting the molecular links between driver and susceptibility genes in colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
retrieved
1 January 2018
stated in
In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20936
determination method or standard
IPI
cell component
biological process

Identifiers

 
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