Wikidata

(Q21104798)

English

CRK like proto-oncogene, adaptor protein

mammalian protein found in Homo sapiens

  • CRKL
  • crk-like protein
  • v-crk avian sarcoma virus CT10 oncogene homolog-like
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
20 references
retrieved
8 April 2019
stated in
DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV
GOA
curator
UniProt
UniProt protein ID
P46109
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of p87C3G, a novel, truncated C3G isoform that is overexpressed in chronic myeloid leukemia and interacts with Bcr-Abl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
retrieved
8 April 2019
stated in
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46109
determination method or standard
IPI
cell component
biological process

Identifiers

 
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