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Egl-9 family hypoxia inducible factor 3
mammalian protein found in Homo sapiens
hypoxia-inducible factor prolyl hydroxylase 3
PHD3
egl nine-like protein 3 isoform
HIF-PH3
HPH-1
prolyl hydroxylase domain-containing protein 3
HIF-prolyl hydroxylase 3
egl nine homolog 3
HPH-3
EGLN3
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9H6Z9
part of
Prolyl 4-hydroxylase, alpha subunit, protein family
1 reference
based on heuristic
inferred from protein domain or family
Oxoglutarate/iron-dependent dioxygenase family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9H6Z9
encoded by
EGLN3
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9H6Z9
molecular function
2-oxoglutarate-dependent dioxygenase activity
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IDA
iron ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
L-ascorbic acid binding
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
dioxygenase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
metal ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
Prolyl hydroxylase domain protein 3 targets Pax2 for destruction
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
retrieved
8 April 2019
stated in
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IPI
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
oxidoreductase activity
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
peptidyl-proline 4-dioxygenase activity
determination method
IDA
EXP
4 references
retrieved
8 April 2019
stated in
A conserved family of prolyl-4-hydroxylases that modify HIF
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IDA
retrieved
8 April 2019
stated in
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
EXP
retrieved
8 April 2019
stated in
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
EXP
retrieved
8 April 2019
stated in
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
EXP
cell component
nucleoplasm
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
TAS
nucleus
determination method
IEA
IDA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
retrieved
8 April 2019
stated in
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IDA
cytoplasm
determination method
IEA
IDA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
retrieved
8 April 2019
stated in
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IDA
cytosol
determination method
IDA
TAS
2 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IDA
biological process
response to hypoxia
determination method
IEP
1 reference
retrieved
8 April 2019
stated in
PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEP
regulation of neuron apoptotic process
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
ISS
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
A conserved family of prolyl-4-hydroxylases that modify HIF
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IDA
cellular response to DNA damage stimulus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
regulation of cell population proliferation
determination method
IEP
1 reference
retrieved
8 April 2019
stated in
PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEP
regulation of transcription from RNA polymerase II promoter in response to hypoxia
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
TAS
activation of cysteine-type endopeptidase activity involved in apoptotic process
determination method
IEP
1 reference
retrieved
8 April 2019
stated in
PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEP
protein hydroxylation
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IDA
apoptotic process
determination method
IEA
IEP
2 references
retrieved
8 April 2019
stated in
PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H6Z9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H6Z9
determination method
IEA
exact match
https://identifiers.org/uniprot:Q9H6Z9
1 reference
stated in
Identifiers.org
UniProt protein ID
Q9H6Z9
reference URL
https://registry.identifiers.org/registry/uniprot
http://purl.uniprot.org/uniprot/Q9H6Z9
1 reference
stated in
Identifiers.org
UniProt protein ID
Q9H6Z9
reference URL
https://registry.identifiers.org/registry/uniprot
https://www.ncbi.nlm.nih.gov/protein/Q9H6Z9
1 reference
stated in
Identifiers.org
UniProt protein ID
Q9H6Z9
reference URL
https://registry.identifiers.org/registry/uniprot
has part(s)
Oxoglutarate/iron-dependent dioxygenase
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9H6Z9
Prolyl 4-hydroxylase, alpha subunit
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9H6Z9
Identifiers
RefSeq protein ID
NP_001295032
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
112399
NP_071356
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
112399
UniProt protein ID
Q9H6Z9
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9H6Z9
Ensembl protein ID
ENSP00000250457
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000250457
ENSP00000446572
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000446572
ENSP00000447470
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000447470
ENSP00000451316
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000451316
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