Wikidata

(Q21104930)

English

ACD shelterin complex subunit and telomerase recruitment factor

mammalian protein found in Homo sapiens

  • adrenocortical dysplasia protein homolog
  • POT1 and TIN2-interacting protein
  • adrenocortical dysplasia homolog
  • TIN2 interacting protein 1
  • ACD
In more languages

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
8 April 2019
stated in
OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation
GOA
curator
UniProt
UniProt protein ID
Q96AP0
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
Telomere protection by mammalian Pot1 requires interaction with Tpp1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
The POT1-TPP1 telomere complex is a telomerase processivity factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
The human CST complex is a terminator of telomerase activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
PTOP interacts with POT1 and regulates its localization to telomeres
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
retrieved
8 April 2019
stated in
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IPI
cell component
shelterin complex
determination method
IBA
IDA
IEA
IMP
TAS
6 references
retrieved
8 April 2019
stated in
The POT1-TPP1 telomere complex is a telomerase processivity factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
TAS
retrieved
8 April 2019
stated in
Characterization of the DNA binding specificity of Shelterin complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IEA
retrieved
8 April 2019
stated in
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IDA
retrieved
8 April 2019
stated in
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IBA
biological process
telomere capping
determination method
IEA
NAS
IGI
IDA
TAS
7 references
retrieved
31 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0
determination method
TAS
retrieved
31 October 2017
stated in
The POT1-TPP1 telomere complex is a telomerase processivity factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0
determination method
TAS
retrieved
31 October 2017
stated in
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0
determination method
NAS
retrieved
31 October 2017
stated in
Telomere protection by mammalian Pot1 requires interaction with Tpp1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0
determination method
IGI
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0
determination method
IEA
retrieved
31 October 2017
stated in
The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96AP0&geneProductId=UniProtKB:Q96AP0
determination method
IDA
telomere capping
determination method
IBA
IDA
IEA
IGI
NAS
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
TAS
retrieved
8 April 2019
stated in
The POT1-TPP1 telomere complex is a telomerase processivity factor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
TAS
retrieved
8 April 2019
stated in
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
NAS
retrieved
8 April 2019
stated in
Telomere protection by mammalian Pot1 requires interaction with Tpp1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IEA
retrieved
8 April 2019
stated in
The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AP0
determination method
IBA

Identifiers

 
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