(Q21105911)

http://www.ebi.ac.uk/interpro/protein/O75367

Core histone macro-H2A

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75367

Histone H2A, C-terminal domain, protein family

1 reference

Macro domain, protein family

1 reference

Core histone macro-H2A, macro domain, protein family

1 reference

Histone H2A/H2B/H3, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

protein kinase binding

1 reference

8 April 2019

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

rDNA binding

1 reference

8 April 2019

macroH2A1 histone variant represses rDNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

protein serine/threonine kinase inhibitor activity

1 reference

8 April 2019

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Macro histone variants are critical for the differentiation of human pluripotent cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

chromatin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

double-stranded methylated DNA binding

1 reference

8 April 2019

macroH2A1 histone variant represses rDNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

protein heterodimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

1 reference

8 April 2019

RNA polymerase II core promoter sequence-specific DNA binding

1 reference

8 April 2019

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

DNA binding

Isolation of cDNA clones encoding human histone macroH2A1 subtypes

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

26 September 2017

enzyme binding

1 reference

8 April 2019

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

protein binding

4 references

8 April 2019

ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

nucleosomal DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

DNA binding

Isolation of cDNA clones encoding human histone macroH2A1 subtypes

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

IBA

cell component

extracellular exosome

ESC/E(Z) complex

1 reference

26 September 2017

The histone variant macroH2A is an epigenetic regulator of key developmental genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

nucleolus

1 reference

8 April 2019

macroH2A1 histone variant represses rDNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

condensed chromosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

1 reference

8 April 2019

pericentric heterochromatin

1 reference

8 April 2019

The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

nucleosome

Isolation of cDNA clones encoding human histone macroH2A1 subtypes

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

5 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

26 September 2017

Proteomic characterization of the human sperm nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

26 September 2017

nuclear chromosome

1 reference

8 April 2019

Weak but uniform enrichment of the histone variant macroH2A1 along the inactive X chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

sex chromatin

TAS

1 reference

8 April 2019

The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

TAS

chromatin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

8 April 2019

Proteomic characterization of the human sperm nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

HDA

extracellular exosome

HDA

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of histone H3-K4 methylation

HDA

biological process

1 reference

8 April 2019

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

regulation of ribosomal DNA heterochromatin assembly

1 reference

8 April 2019

macroH2A1 histone variant represses rDNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

dosage compensation

1 reference

8 April 2019

Respiratory complex III is required to maintain complex I in mammalian mitochondria

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of cell cycle G2/M phase transition

1 reference

8 April 2019

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

epigenetic maintenance of chromatin in transcription-competent conformation

1 reference

8 April 2019

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

regulation of cell growth

IGI

1 reference

26 September 2017

macroH2A1 histone variant represses rDNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

positive regulation of keratinocyte differentiation

IGI

1 reference

8 April 2019

Macro histone variants are critical for the differentiation of human pluripotent cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of protein serine/threonine kinase activity

1 reference

8 April 2019

Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

The histone variant macroH2A is an epigenetic regulator of key developmental genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of protein localization to chromosome, telomeric region

1 reference

8 April 2019

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of gene expression, epigenetic

3 references

8 April 2019

Macro histone variants are critical for the differentiation of human pluripotent cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

The histone variant macroH2A is an epigenetic regulator of key developmental genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

macroH2A1 histone variant represses rDNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of histone H3-K27 methylation

1 reference

8 April 2019

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

regulation of gene expression, epigenetic

1 reference

8 April 2019

The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

positive regulation of maintenance of mitotic sister chromatid cohesion

1 reference

8 April 2019

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

establishment of protein localization to chromatin

1 reference

8 April 2019

The histone variant macroH2A is an epigenetic regulator of key developmental genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of transcription of nucleolar large rRNA by RNA polymerase I

macroH2A1 histone variant represses rDNA transcription

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

macroH2A1 histone variant represses rDNA transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

negative regulation of response to oxidative stress

1 reference

26 September 2017

Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

positive regulation of response to oxidative stress

1 reference

26 September 2017

Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75367&geneProductId=UniProtKB:O75367

regulation of lipid metabolic process

1 reference

8 April 2019

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75367

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016