(Q21106096)

English

WASH complex subunit 2C

mammalian protein found in Homo sapiens

WASHC2C
VPEF
vaccinia virus penetration factor
WASH complex subunit FAM21C
family with sequence similarity 21 member C

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Statements

1 reference

13 November 2019

transporter of unknown biochemical mechanism

1 reference

Transporter Classification Database ID

9.A.3.1.2

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

FAM21/CAPZIP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

phosphatidylinositol-3-phosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-3,5-bisphosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-3,4-bisphosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-4-phosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-5-phosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

5 references

8 April 2019

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

8 April 2019

A FAM21-containing WASH complex regulates retromer-dependent sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

8 April 2019

Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

8 April 2019

Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

8 April 2019

RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IPI

phosphatidylinositol-4,5-bisphosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

phosphatidylinositol-3,4,5-trisphosphate binding

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IEA

retromer complex binding

1 reference

16 July 2018

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4E1&geneProductId=UniProtKB:Q9Y4E1

determination method

IMP

retromer complex binding

early endosome membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IEA

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

16 July 2018

Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4E1&geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

A FAM21-containing WASH complex regulates retromer-dependent sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

biological process

negative regulation of barbed-end actin filament capping

1 reference

8 April 2019

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

retrograde transport, endosome to Golgi

1 reference

8 April 2019

A FAM21-containing WASH complex regulates retromer-dependent sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IEA

regulation of substrate adhesion-dependent cell spreading

1 reference

8 April 2019

Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

determination method

IDA

protein localization to endosome

1 reference

8 April 2019

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4E1

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9Y4E1

Identifiers

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13 November 2019

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Transporter Classification Database ID

9.A.3.1.2

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

(Q21106096)

WASH complex subunit 2C

Statements

Identifiers

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