Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q21106105)
Watch
English
Klotho beta
mammalian protein found in Homo sapiens
beta-klotho
klotho beta-like protein
betaKlotho
KLB
klotho beta like
b-Klotho
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q86Z14
part of
glycoside hydrolase superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q86Z14
Glycoside hydrolase family 1
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q86Z14
auxiliary protein involved in transmembrane transport
1 reference
Transporter Classification Database ID
8.A.49.1.2
retrieved
2 October 2019
based on heuristic
hierarchical database ID heuristic
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q86Z14
encoded by
KLB
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q86Z14
molecular function
hydrolase activity, hydrolyzing O-glycosyl compounds
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IEA
fibroblast growth factor receptor binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Liver-specific activities of FGF19 require Klotho beta
GOA
curator
UniProt
UniProt protein ID
Q86Z14
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IPI
fibroblast growth factor binding
determination method
IPI
2 references
retrieved
8 April 2019
stated in
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors
GOA
curator
UniProt
UniProt protein ID
Q86Z14
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IPI
retrieved
8 April 2019
stated in
Different roles of N- and C- termini in the functional activity of FGF21
GOA
curator
UniProt
UniProt protein ID
Q86Z14
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IPI
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
FGF21 N- and C-termini play different roles in receptor interaction and activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IPI
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
determination method
TAS
1 reference
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
TAS
1-phosphatidylinositol-3-kinase activity
determination method
TAS
1 reference
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
TAS
beta-glucosidase activity
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
IBA
cell component
integral component of membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Z14
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Z14
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IEA
plasma membrane
determination method
TAS
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q86Z14
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IEA
integral component of plasma membrane
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
IBA
intracellular anatomical structure
determination method
IEA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
IEA
biological process
MAPK cascade
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
TAS
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IEA
positive regulation of cell population proliferation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IEA
glycosyl compound metabolic process
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
IBA
phosphatidylinositol-3-phosphate biosynthetic process
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
IEA
phosphatidylinositol phosphate biosynthetic process
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
IEA
fibroblast growth factor receptor signaling pathway
determination method
TAS
IBA
IEA
3 references
retrieved
27 March 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
TAS
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
IEA
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Z14&geneProductId=UniProtKB:Q86Z14
determination method
IBA
carbohydrate metabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IEA
positive regulation of protein kinase B signaling
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
TAS
fibroblast growth factor receptor signaling pathway
determination method
IEA
TAS
2 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Z14
determination method
IEA
Identifiers
RefSeq protein ID
NP_783864
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
152831
UniProt protein ID
Q86Z14
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q86Z14
Ensembl protein ID
ENSP00000257408
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000257408
Transporter Classification Database ID
8.A.49.1.2
2 references
stated in
Transporter Classification database
retrieved
13 March 2020
stated in
Transporter Classification database
retrieved
29 April 2020
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
