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(Q21106570)
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Serine peptidase inhibitor Kazal type 2
mammalian protein found in Homo sapiens
SPINK2
epididymis tissue protein Li 172
Acrosin-trypsin inhibitor
HUSI-II
serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
serine protease inhibitor Kazal-type 2
In more languages
default for all languages
No label defined
No description defined
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P20155
part of
Kazal domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P20155
Kazal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P20155
encoded by
SPINK2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P20155
molecular function
peptidase inhibitor activity
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IEA
endopeptidase inhibitor activity
determination method
TAS
1 reference
retrieved
9 May 2019
stated in
Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II)
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
TAS
protein binding
determination method
IPI
1 reference
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IPI
serine-type endopeptidase inhibitor activity
determination method
IBA
IEA
3 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IEA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IBA
cell component
extracellular region
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IEA
acrosomal vesicle
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P20155&geneProductId=UniProtKB:P20155
determination method
IBA
extracellular space
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P20155&geneProductId=UniProtKB:P20155
determination method
IBA
acrosomal vesicle
determination method
IBA
IDA
2 references
retrieved
7 November 2018
stated in
SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P20155&geneProductId=UniProtKB:P20155
determination method
IDA
retrieved
7 November 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P20155&geneProductId=UniProtKB:P20155
determination method
IBA
acrosomal vesicle
determination method
IBA
IDA
IEA
3 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IEA
retrieved
9 May 2019
stated in
SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IBA
cytoplasmic vesicle
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IEA
biological process
regulation of acrosome reaction
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P20155&geneProductId=UniProtKB:P20155
determination method
IBA
negative regulation of peptidase activity
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IEA
negative regulation of serine-type endopeptidase activity
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IBA
spermatogenesis
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IBA
acrosome assembly
determination method
ISS
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
ISS
spermatid development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IMP
spermatid development
determination method
IEA
IMP
2 references
retrieved
9 May 2019
stated in
SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes
GOA
curator
UniProt
UniProt protein ID
P20155
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20155
determination method
IEA
has part(s)
Kazal domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P20155
Identifiers
RefSeq protein ID
NP_001258647
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
NP_001258648
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
NP_001258649
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
NP_001258650
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
NP_001258651
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
NP_066937
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
XP_011532707
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
XP_011532708
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
XP_024309959
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
6691
UniProt protein ID
P20155
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P20155
Ensembl protein ID
ENSP00000248701
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000248701
ENSP00000423858
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000423858
ENSP00000425961
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000425961
ENSP00000477722
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000477722
ENSP00000478284
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000478284
ENSP00000487028
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000487028
PDB structure ID
2JXD
1 reference
stated in
UniProt
UniProt protein ID
P20155
retrieved
21 March 2016
language of work or name
English
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