(Q21106584)

http://www.ebi.ac.uk/interpro/protein/P68106

FKBP

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

ryanodine-sensitive calcium-release channel activity

1 reference

9 May 2019

Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

peptidyl-prolyl cis-trans isomerase activity

4 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P68106&geneProductId=UniProtKB:P68106

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P68106&geneProductId=UniProtKB:P68106

31 January 2018

A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P68106&geneProductId=UniProtKB:P68106

31 January 2018

Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P68106&geneProductId=UniProtKB:P68106

5 references

9 May 2019

FKBP binding characteristics of cardiac microsomes from diverse vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

signaling receptor binding

IPI

cyclic nucleotide binding

IPI

2 references

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

peptidyl-prolyl cis-trans isomerase activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P68106&geneProductId=UniProtKB:P68106

10 September 2018

A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P68106&geneProductId=UniProtKB:P68106

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P68106&geneProductId=UniProtKB:P68106

intracellular membrane-bounded organelle

IBA

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

1 reference

9 May 2019

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

1 reference

9 May 2019

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

sarcoplasmic reticulum membrane

1 reference

9 May 2019

A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

smooth muscle contraction

IBA

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

regulation of ryanodine-sensitive calcium-release channel activity

3 references

9 May 2019

A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

release of sequestered calcium ion into cytosol

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

regulation of cardiac conduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

regulation of cytosolic calcium ion concentration

3 references

9 May 2019

Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

9 May 2019

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

positive regulation of cytosolic calcium ion concentration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

cell communication by electrical coupling involved in cardiac conduction

1 reference

9 May 2019

Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

negative regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

positive regulation of axon regeneration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

protein maturation by protein folding

1 reference

9 May 2019

Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

response to organic substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

response to vitamin E

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

regulation of heart rate

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

negative regulation of ryanodine-sensitive calcium-release channel activity

1 reference

9 May 2019

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease

response to redox state

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

ion transmembrane transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

positive regulation of sequestering of calcium ion

1 reference

9 May 2019

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

neuronal action potential propagation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

1 reference

9 May 2019

Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

negative regulation of release of sequestered calcium ion into cytosol

1 reference

9 May 2019

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

'de novo' protein folding

1 reference

9 May 2019

Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

calcium-mediated signaling using intracellular calcium source

1 reference

9 May 2019

Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

response to hydrogen peroxide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

chaperone-mediated protein folding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

negative regulation of phosphoprotein phosphatase activity

IBA

1 reference

9 May 2019

A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P68106

FKBP-type peptidyl-prolyl cis-trans isomerase domain

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P68106

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016